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HomoloGene:7934. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   SHC1,  H.sapiens
SHC (Src homology 2 domain containing) transforming protein 1
    NP_001123512.1
584 aa
   SHC1,  P.troglodytes
SHC (Src homology 2 domain containing) transforming protein 1
    XP_513843.3
583 aa
   SHC1,  M.mulatta
SHC (Src homology 2 domain containing) transforming protein 1
    XP_001112447.2
584 aa
   SHC1,  C.lupus
SHC (Src homology 2 domain containing) transforming protein 1
    XP_547561.1
576 aa
   SHC1,  B.taurus
SHC (Src homology 2 domain containing) transforming protein 1
    NP_001157533.1
583 aa
   Shc1,  M.musculus
src homology 2 domain-containing transforming protein C1
    NP_001106802.1
579 aa
   Shc1,  R.norvegicus
SHC (Src homology 2 domain containing) transforming protein 1
    NP_001157532.1
579 aa
   SHC1,  G.gallus
SHC (Src homology 2 domain containing) transforming protein 1
    XP_424373.4
619 aa
   LOC100492349,  X.tropicalis
SHC-transforming protein 1-like
    XP_004920599.1
416 aa
   shc1,  D.rerio
SHC (Src homology 2 domain containing) transforming protein 1
    XP_005169812.1
454 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

p66Shc, mitochondria, and the generation of reactive oxygen species.
Trinei M, et al. Methods Enzymol 528, 99-110 (2013).
The p66(Shc) gene paves the way for healthspan: evolutionary and mechanistic perspectives.
Berry A & Cirulli F. Neurosci Biobehav Rev 37, 790-802 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
SH2 (cl15255)
  Src homology 2 (SH2) domain.
PH-like (cl17171)
  Pleckstrin homology-like domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Shc1 includes H.sapiens SHC1 and R.norvegicus Shc1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (14 transcripts, 11 species)
Actinopterygii - bony fishes (9 transcripts, 7 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Aves - birds (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)

Arthropoda
Insecta - insects (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Platyhelminthes
Turbellaria - flatworms (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (2 transcripts, 1 species)

 

 

 

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