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HomoloGene:466. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   VWF,  H.sapiens
von Willebrand factor
    NP_000543.2
2813 aa
   VWF,  P.troglodytes
von Willebrand factor
    XP_001160508.1
2813 aa
   VWF,  M.mulatta
von Willebrand factor
    XP_002808020.1
2704 aa
   VWF,  C.lupus
von Willebrand factor
    NP_001002932.1
2813 aa
   VWF,  B.taurus
von Willebrand factor
    NP_001192237.1
2809 aa
   Vwf,  M.musculus
Von Willebrand factor homolog
    NP_035838.3
2813 aa
   Vwf,  R.norvegicus
von Willebrand factor
    NP_446341.1
2812 aa
   VWF,  G.gallus
von Willebrand factor
    XP_417223.3
2800 aa
   vwf,  X.tropicalis
von Willebrand factor
    NP_001243217.1
2842 aa
   vwf,  D.rerio
von Willebrand factor
    XP_002665356.3
2812 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
von Willebrand disease.



Publications
Articles associated with genes and sequences of this homology group.

[Detection of hemophilia A carrier by FⅧ:C/vWFAg ratio].
An L, et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 30, 721-3 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
VWC (cl02515)
  von Willebrand factor type C domain.
VWC_out (smart00215)
  von Willebrand factor (vWF) type C domain.
VWC (pfam00093)
  von Willebrand factor type C domain.
TIL (pfam01826)
  Trypsin Inhibitor like cysteine rich domain.
C8 (pfam08742)
  C8 domain.
TIL (pfam01826)
  Trypsin Inhibitor like cysteine rich domain.
vWFA (cl00057)
  Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
VWD (cl02516)
  von Willebrand factor type D domain.
C8 (cl07383)
  This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.
DAN (cl17734)
  DAN domain.
VWC (cl17735)
  von Willebrand factor type C domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Vwf includes H.sapiens VWF and R.norvegicus Vwf.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (8 transcripts, 7 species)
Aves - birds (2 transcripts, 1 species)
Amniota - vertebrates (1 transcript, 1 species)

 

 

 

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