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HomoloGene:117702. Gene conserved in Tetrapoda Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   TNFRSF10B,  H.sapiens
tumor necrosis factor receptor superfamily, member 10b
    NP_003833.4
440 aa
   TNFRSF10B,  P.troglodytes
tumor necrosis factor receptor superfamily, member 10b
    XP_001158074.1
410 aa
   LOC716650,  M.mulatta
tumor necrosis factor receptor superfamily member 10B-like
    XP_001107490.2
519 aa
   TNFRSF10B,  G.gallus
tumor necrosis factor receptor superfamily, member 10b
    NP_989446.2
368 aa
   tnfrsf10b,  X.tropicalis
tumor necrosis factor receptor superfamily, member 10b
    NP_001004894.1
321 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Squamous cell carcinoma, head and neck.



Publications
Articles associated with genes and sequences of this homology group.

TRAIL: not just for tumors anymore?
Benedict CA & Ware CF. J Exp Med 209, 1903-6 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Death_TRAILR_DR4_DR5 (cd08315)
  Death domain of Tumor necrosis factor-Related Apoptosis-Inducing Ligand Receptors.
TNFR (cd00185)
  Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and ...
DD_superfamily (cl14633)
  The Death Domain Superfamily of protein-protein interaction domains.
TNFR_c6 (cl12111)
  Repeats in growth factor receptors that are involved in growth factor binding. TNF/TNFR
DD (cl14633)
  Death Domain Superfamily of protein-protein interaction domains.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (2 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)

 

 

 

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