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HomoloGene:4224. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   TNK2,  H.sapiens
tyrosine kinase, non-receptor, 2
1038 aa
   TNK2,  M.mulatta
tyrosine kinase, non-receptor, 2
1038 aa
   TNK2,  C.lupus
tyrosine kinase, non-receptor, 2
1083 aa
   TNK2,  B.taurus
tyrosine kinase, non-receptor, 2
1039 aa
   Tnk2,  M.musculus
tyrosine kinase, non-receptor, 2
1055 aa
   Tnk2,  R.norvegicus
tyrosine kinase, non-receptor, 2
1040 aa
   TNK2,  G.gallus
tyrosine kinase, non-receptor, 2
1203 aa
   tnk2,  X.tropicalis
tyrosine kinase, non-receptor, 2
1066 aa
   LOC559119,  D.rerio
activated CDC42 kinase 1-like
1093 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Cancer-associated mutations activate the nonreceptor tyrosine kinase Ack1.
Prieto-Echag├╝e V, et al. J Biol Chem 285, 10605-15 (2010).
Expression pattern of ACK1 tyrosine kinase during brain development in the mouse.
La Torre A, et al. Gene Expr Patterns 6, 886-92 (2006).
Purification and enzyme activity of ACK1.
Yokoyama N & Miller WT. Methods Enzymol 406, 250-60 (2006).
Metastatic properties and genomic amplification of the tyrosine kinase gene ACK1.
van der Horst EH, et al. Proc Natl Acad Sci U S A 102, 15901-6 (2005).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
GTPase_binding (pfam09027)
  GTPase binding.
Inhibitor_Mig-6 (pfam11555)
  EGFR receptor inhibitor Mig-6.
UBA (pfam00627)
  UBA/TS-N domain.
UBA (cl00153)
  Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been suggested that UBA domains are involved in conferring protein target specificity. The domain, a compact three helix bundle, has a conserved GFP-loop and the proline is thought to be critical for binding. The UBA domain is distinct from the conserved three helical domain seen in the N-terminus of EF-TS and eukaryotic NAC proteins.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
SAM_superfamily (cl15755)
  SAM (Sterile alpha motif ).
SH3 (cl17036)
  Src Homology 3 domain superfamily.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Tnk2 includes H.sapiens TNK2 and R.norvegicus Tnk2.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (12 transcripts, 9 species)
Actinopterygii - bony fishes (8 transcripts, 6 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Echinoidea - sea urchins (2 transcripts, 2 species)

Chromadorea - nematodes (1 transcript, 1 species)




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