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HomoloGene:314. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   TSC1,  H.sapiens
tuberous sclerosis 1
    NP_000359.1
1164 aa
   TSC1,  P.troglodytes
tuberous sclerosis 1
    XP_001168992.1
1163 aa
   TSC1,  M.mulatta
tuberous sclerosis 1
    XP_001103846.2
1113 aa
   TSC1,  C.lupus
tuberous sclerosis 1
    XP_005625233.1
1169 aa
   TSC1,  B.taurus
tuberous sclerosis 1
    XP_005213508.1
1160 aa
   Tsc1,  M.musculus
tuberous sclerosis 1
    NP_075025.2
1160 aa
   Tsc1,  R.norvegicus
tuberous sclerosis 1
    NP_068626.1
1163 aa
   TSC1,  G.gallus
tuberous sclerosis 1
    XP_415449.2
1156 aa
   tsc1,  X.tropicalis
tuberous sclerosis 1
    XP_002944681.2
1116 aa
   tsc1a,  D.rerio
tuberous sclerosis 1a
    NP_956346.1
1128 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Tuberous sclerosis-1.
Lymphangioleiomyomatosis.
Focal cortical dysplasia, Taylor balloon cell type.



Publications
Articles associated with genes and sequences of this homology group.

TSC1 regulates the balance between effector and regulatory T cells.
Park Y, et al. J Clin Invest 123, 5165-78 (2013).
Inhibition of AMPK catabolic action by GSK3.
Suzuki T, et al. Mol Cell 50, 407-19 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
NAT_SF (cl00357)
  N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate.
Hamartin (pfam04388)
  Hamartin protein.
BAR (cl12013)
  The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature.
Hamartin (pfam04388)
  Hamartin protein.
DUF4515 (pfam14988)
  Domain of unknown function (DUF4515).
Lebercilin (pfam15619)
  Ciliary protein causing Leber congenital amaurosis disease.
ApoLp-III_like (cl19113)
  Apolipophorin-III and similar insect proteins.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Tsc1 includes H.sapiens TSC1 and R.norvegicus Tsc1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (16 transcripts, 9 species)
Actinopterygii - bony fishes (3 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (3 transcripts, 3 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

 

 

 

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