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HomoloGene:167. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   SGSH,  H.sapiens
N-sulfoglucosamine sulfohydrolase
    NP_000190.1
502 aa
   SGSH,  M.mulatta
N-sulfoglucosamine sulfohydrolase
    XP_001110101.2
502 aa
   SGSH,  C.lupus
N-sulfoglucosamine sulfohydrolase
    NP_001003114.1
507 aa
   SGSH,  B.taurus
N-sulfoglucosamine sulfohydrolase
    NP_001095659.2
505 aa
   Sgsh,  M.musculus
N-sulfoglucosamine sulfohydrolase (sulfamidase)
    NP_061292.2
502 aa
   SGSH,  G.gallus
N-sulfoglucosamine sulfohydrolase
    XP_420084.4
575 aa
   sgsh,  X.tropicalis
N-sulfoglucosamine sulfohydrolase
    NP_001120065.1
503 aa
   sgsh,  D.rerio
N-sulfoglucosamine sulfohydrolase (sulfamidase)
    NP_001116740.1
511 aa
   CG14291,  D.melanogaster
CG14291
    NP_650760.1
524 aa
   AgaP_AGAP004205,  A.gambiae
AgaP_AGAP004205
    XP_313106.2
502 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Sanfilippo syndrome, type A.



Publications
Articles associated with genes and sequences of this homology group.

Enzyme replacement reduces neuropathology in MPS IIIA dogs.
Crawley AC, et al. Neurobiol Dis 43, 422-34 (2011).
Lentiviral-mediated gene therapy for murine mucopolysaccharidosis type IIIA.
McIntyre C, et al. Mol Genet Metab 93, 411-8 (2008).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
AslA (COG3119)
  Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism].
Sulfatase (cl19157)
  Sulfatase.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Sgsh includes H.sapiens SGSH.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (10 transcripts, 10 species)
Actinopterygii - bony fishes (10 transcripts, 9 species)
Aves - birds (3 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (10 transcripts, 8 species)
Arachnida - arachnids (2 transcripts, 1 species)

Echinodermata
Echinoidea - sea urchins (3 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

 

 

 

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