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HomoloGene:31052. Gene conserved in Tetrapoda Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   CD22,  H.sapiens
CD22 molecule
847 aa
   CD22,  P.troglodytes
CD22 molecule
847 aa
   CD22,  C.lupus
CD22 molecule
845 aa
   CD22,  B.taurus
CD22 molecule
843 aa
   Cd22,  M.musculus
CD22 antigen
868 aa
   Cd22,  R.norvegicus
CD22 molecule
852 aa
   cd22,  X.tropicalis
CD22 molecule
838 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

CD22 ligand-binding and signaling domains reciprocally regulate B-cell Ca2+ signaling.
Müller J, et al. Proc Natl Acad Sci U S A 110, 12402-7 (2013).
CD22 and autoimmune disease.
Dörner T, et al. Int Rev Immunol 31, 363-78 (2012).
CD22 serves as a receptor for soluble IgM.
Adachi T, et al. Eur J Immunol 42, 241-7 (2012).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
I-set (pfam07679)
  Immunoglobulin I-set domain.
IGc2 (smart00408)
  Immunoglobulin C-2 Type.
Ig_2 (pfam13895)
  Immunoglobulin domain.
IG (smart00409)
IG_like (smart00410)
  Immunoglobulin like.
Ig (cl11960)
  Immunoglobulin domain.
I-set (pfam07679)
  Immunoglobulin I-set domain.
Ig (cl11960)
  Immunoglobulin domain.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Cd22 includes H.sapiens CD22 and R.norvegicus Cd22.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (5 transcripts, 4 species)
Actinopterygii - bony fishes (1 transcript, 1 species)




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