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HomoloGene:3598. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   H2AFY,  H.sapiens
H2A histone family, member Y
372 aa
   H2AFY,  P.troglodytes
core histone macro-H2A.1
372 aa
   H2AFY,  M.mulatta
H2A histone family, member Y
372 aa
   H2AFY,  C.lupus
H2A histone family, member Y
372 aa
   H2AFY,  B.taurus
H2A histone family, member Y
371 aa
   H2afy,  M.musculus
H2A histone family, member Y
372 aa
   H2afy,  R.norvegicus
H2A histone family, member Y
371 aa
   H2AFY,  G.gallus
H2A histone family, member Y
372 aa
   h2afy,  X.tropicalis
H2A histone family, member Y
369 aa
   h2afy,  D.rerio
H2A histone family, member Y
357 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Genome-wide distribution of macroH2A1 histone variants in mouse liver chromatin.
Changolkar LN, et al. Mol Cell Biol 30, 5473-83 (2010).
Histone variant macroH2A1 deletion in mice causes female-specific steatosis.
Boulard M, et al. Epigenetics Chromatin 3, 8 (2010).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
H2A (cd00074)
  Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...
Macro (cl00019)
  Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus H2afy includes H.sapiens H2AFY and R.norvegicus H2afy.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (18 transcripts, 14 species)
Actinopterygii - bony fishes (7 transcripts, 7 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Hydrozoa - hydrozoans (2 transcripts, 2 species)
Anthozoa - anthozoans (2 transcripts, 1 species)

Gastropoda - gastropods (1 transcript, 1 species)

Turbellaria - flatworms (1 transcript, 1 species)

Echinoidea - sea urchins (1 transcript, 1 species)




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