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HomoloGene:55484. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   CACNA1C,  H.sapiens
calcium channel, voltage-dependent, L type, alpha 1C subunit
    NP_955630.2
2221 aa
   CACNA1C,  P.troglodytes
calcium channel, voltage-dependent, L type, alpha 1C subunit
    XP_003313479.1
1828 aa
   CACNA1C,  M.mulatta
calcium channel, voltage-dependent, L type, alpha 1C subunit
    XP_001117926.2
2165 aa
   CACNA1C,  C.lupus
calcium channel, voltage-dependent, L type, alpha 1C subunit
    XP_005637433.1
2242 aa
   Cacna1c,  M.musculus
calcium channel, voltage-dependent, L type, alpha 1C subunit
    NP_001242928.1
2169 aa
   Cacna1c,  R.norvegicus
calcium channel, voltage-dependent, L type, alpha 1C subunit
    NP_036649.2
2170 aa
   CACNA1C,  G.gallus
calcium channel, voltage-dependent, L type, alpha 1C subunit
    XP_416388.4
2220 aa
   cacna1c,  X.tropicalis
calcium channel, voltage-dependent, L type, alpha 1C subunit
    XP_002938148.2
2205 aa
   cacna1c,  D.rerio
calcium channel, voltage-dependent, L type, alpha 1C subunit
    NP_571975.1
2168 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Timothy syndrome.



Publications
Articles associated with genes and sequences of this homology group.

A naturally occurring truncated Cav1.2 α1-subunit inhibits Ca2+ current in A7r5 cells.
Cox RH & Fromme SJ. Am J Physiol Cell Physiol 305, C896-905 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Etmic-2 (pfam06670)
  Microneme protein Etmic-2.
Ca_chan_IQ (cl07394)
  Voltage gated calcium channel IQ domain.
Ion_trans (pfam00520)
  Ion transport protein.
Ion_trans (pfam00520)
  Ion transport protein.
TrbL (cl01503)
  TrbL/VirB6 plasmid conjugal transfer protein.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Cacna1c includes H.sapiens CACNA1C and R.norvegicus Cacna1c.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (16 transcripts, 10 species)
Actinopterygii - bony fishes (6 transcripts, 3 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Arthropoda
Insecta - insects (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

 

 

 

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