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HomoloGene:47607. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   LIN28B,  H.sapiens
lin-28 homolog B (C. elegans)
    NP_001004317.1
250 aa
   LIN28B,  P.troglodytes
lin-28 homolog B (C. elegans)
    XP_001143220.1
250 aa
   LIN28B,  M.mulatta
lin-28 homolog B (C. elegans)
    XP_001086990.1
248 aa
   LIN28B,  C.lupus
lin-28 homolog B (C. elegans)
    XP_539064.2
251 aa
   LIN28B,  B.taurus
lin-28 homolog B (C. elegans)
    XP_002707884.3
460 aa
   Lin28b,  M.musculus
lin-28 homolog B (C. elegans)
    NP_001026942.1
271 aa
   Lin28b,  R.norvegicus
lin-28 homolog B (C. elegans)
    XP_006256662.1
280 aa
   LIN28B,  G.gallus
lin-28 homolog B (C. elegans)
    NP_001029990.1
250 aa
   lin28b,  X.tropicalis
lin-28 homolog B
    NP_001135490.1
253 aa
   LOC799825,  D.rerio
protein lin-28 homolog A-like
    XP_001340141.2
193 aa
   lin-28,  D.melanogaster
lin-28
    NP_647983.1
195 aa
   AgaP_AGAP006591,  A.gambiae
AgaP_AGAP006591
    XP_316618.3
182 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Association of LIN28B with adult adiposity-related traits in females.
Leinonen JT, et al. PLoS One 7, e48785 (2012).
A LIN28B polymorphism predicts for colon cancer survival.
Ye Y, et al. Cancer Biol Ther 13, 1390-5 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
AIR1 (COG5082)
  Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion].
Tubulin_FtsZ (cl10017)
  Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved ...
S1_like (cl09927)
  S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain. ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Lin28b includes H.sapiens LIN28B and R.norvegicus Lin28b.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (4 transcripts, 4 species)
Ascidiacea - tunicates (3 transcripts, 2 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (3 transcripts, 3 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Platyhelminthes
Turbellaria - flatworms (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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