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HomoloGene:1986. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PIK3C3,  H.sapiens
phosphatidylinositol 3-kinase, catalytic subunit type 3
    NP_002638.2
887 aa
   PIK3C3,  P.troglodytes
phosphatidylinositol 3-kinase, catalytic subunit type 3
    XP_001142812.1
887 aa
   PIK3C3,  M.mulatta
phosphatidylinositol 3-kinase, catalytic subunit type 3
    XP_001082892.1
887 aa
   PIK3C3,  C.lupus
phosphatidylinositol 3-kinase, catalytic subunit type 3
    XP_547599.3
887 aa
   PIK3C3,  B.taurus
phosphatidylinositol 3-kinase, catalytic subunit type 3
    NP_001092537.1
887 aa
   Pik3c3,  M.musculus
phosphoinositide-3-kinase, class 3
    NP_852079.2
887 aa
   Pik3c3,  R.norvegicus
phosphatidylinositol 3-kinase, catalytic subunit type 3
    NP_075247.1
887 aa
   PIK3C3,  G.gallus
phosphoinositide-3-kinase, class 3
    XP_003642950.2
916 aa
   pik3c3,  X.tropicalis
phosphatidylinositol 3-kinase, catalytic subunit type 3
    XP_002935097.2
887 aa
   pik3c3,  D.rerio
phosphoinositide-3-kinase, class 3
    NP_001017550.2
726 aa
   Pi3K59F,  D.melanogaster
Phosphotidylinositol 3 kinase 59F
    NP_477133.1
949 aa
   AgaP_AGAP010273,  A.gambiae
AgaP_AGAP010273
    XP_319464.4
933 aa
   vps-34,  C.elegans
vps-34
    NP_001020954.1
897 aa
   VPS34,  S.cerevisiae
VPS34
    NP_013341.1
875 aa
   KLLA0D18645g,  K.lactis
KLLA0D18645g
    XP_453887.1
862 aa
   AGOS_AGL113C,  E.gossypii
AGOS_AGL113C
    NP_986554.1
870 aa
   pik3,  S.pombe
pik3
    NP_594699.1
801 aa
   MGG_03069,  M.oryzae
MGG_03069
    XP_003720606.1
927 aa
   NCU00656,  N.crassa
NCU00656
    XP_965796.1
891 aa
   VPS34,  A.thaliana
VPS34
    NP_176251.1
814 aa
   Os05g0180600,  O.sativa
Os05g0180600
    NP_001054810.1
814 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Class III PI3K Vps34 plays an essential role in autophagy and in heart and liver function.
Jaber N, et al. Proc Natl Acad Sci U S A 109, 2003-8 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PI3Kc_like (cl00119)
  Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), ...
PI3Ka (cl00271)
  Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...
HEAT_2 (pfam13646)
  HEAT repeats.
PI3Kc_like (cl00119)
  Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), ...
C2 (cl14603)
  C2 domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Pik3c3 includes H.sapiens PIK3C3 and R.norvegicus Pik3c3.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (14 transcripts, 10 species)
Mammalia - mammals (12 transcripts, 12 species)
Ascidiacea - tunicates (6 transcripts, 3 species)
Aves - birds (3 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)

Arthropoda
Insecta - insects (8 transcripts, 7 species)
Arachnida - arachnids (2 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (5 transcripts, 2 species)

Cnidaria
Anthozoa - anthozoans (2 transcripts, 1 species)
Hydrozoa - hydrozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (3 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (32 transcripts, 25 species)
Liliopsida - monocots (11 transcripts, 9 species)
Coniferopsida - conifers (4 transcripts, 3 species)
Bryopsida - mosses (1 transcript, 1 species)
Isoetopsida - club-mosses (1 transcript, 1 species)

Chlorophyta
Chlorophyceae - green algae (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (3 transcripts, 2 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (2 transcripts, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

Ciliophora
Oligohymenophorea - ciliates (2 transcripts, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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