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HomoloGene:3641. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   GUCY2C,  H.sapiens
guanylate cyclase 2C (heat stable enterotoxin receptor)
    NP_004954.2
1073 aa
   GUCY2C,  P.troglodytes
guanylate cyclase 2C (heat stable enterotoxin receptor)
    XP_528746.2
1073 aa
   GUCY2C,  M.mulatta
guanylate cyclase 2C (heat stable enterotoxin receptor)
    XP_001089601.1
1073 aa
   GUCY2C,  C.lupus
guanylate cyclase 2C (heat stable enterotoxin receptor)
    XP_543798.3
1137 aa
   GUCY2C,  B.taurus
guanylate cyclase 2C (heat stable enterotoxin receptor)
    NP_776972.1
1072 aa
   Gucy2c,  M.musculus
guanylate cyclase 2c
    NP_001120790.1
1072 aa
   Gucy2c,  R.norvegicus
guanylate cyclase 2C
    NP_037302.1
1072 aa
   GUCY2C,  G.gallus
guanylate cyclase 2C (heat stable enterotoxin receptor)
    XP_416207.3
1072 aa
   gucy2c,  X.tropicalis
guanylate cyclase 2C (heat stable enterotoxin receptor)
    XP_002934756.1
1064 aa
   LOC568219,  D.rerio
heat-stable enterotoxin receptor-like
    XP_696628.4
1071 aa
   LOC572052,  D.rerio
heat-stable enterotoxin receptor-like
    XP_700803.6
1025 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
???.



Publications
Articles associated with genes and sequences of this homology group.

Familial diarrhea syndrome caused by an activating GUCY2C mutation.
Fiskerstrand T, et al. N Engl J Med 366, 1586-95 (2012).
A uroguanylin-GUCY2C endocrine axis regulates feeding in mice.
Valentino MA, et al. J Clin Invest 121, 3578-88 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
CYCc (smart00044)
  Adenylyl- / guanylyl cyclase, catalytic domain.
Pkinase_Tyr (pfam07714)
  Protein tyrosine kinase.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
Periplasmic_Binding_Protein_Type_1 (cl10011)
  Type 1 periplasmic binding fold superfamily.
Pkinase_Tyr (pfam07714)
  Protein tyrosine kinase.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
Periplasmic_Binding_Protein_Type_1 (cl10011)
  Type 1 periplasmic binding fold superfamily.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Gucy2c includes H.sapiens GUCY2C and R.norvegicus Gucy2c.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (10 transcripts, 9 species)
Actinopterygii - bony fishes (9 transcripts, 6 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

 

 

 

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