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HomoloGene:13. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   AGA,  H.sapiens
aspartylglucosaminidase
    NP_000018.2
346 aa
   AGA,  P.troglodytes
aspartylglucosaminidase
    XP_517545.2
346 aa
   AGA,  M.mulatta
aspartylglucosaminidase
    XP_001090811.2
297 aa
   AGA,  C.lupus
aspartylglucosaminidase
    XP_005630078.1
343 aa
   AGA,  B.taurus
aspartylglucosaminidase
    NP_001068979.1
250 aa
   Aga,  M.musculus
aspartylglucosaminidase
    NP_001005847.1
346 aa
   Aga,  R.norvegicus
aspartylglucosaminidase
    NP_001026811.1
345 aa
   AGA,  G.gallus
aspartylglucosaminidase
    NP_001006445.1
345 aa
   aga,  X.tropicalis
aspartylglucosaminidase
    XP_002934303.2
347 aa
   aga,  D.rerio
aspartylglucosaminidase
    NP_001103751.1
337 aa
   CG1827,  D.melanogaster
CG1827
    NP_610504.3
377 aa
   CG10474,  D.melanogaster
CG10474
    NP_611404.1
341 aa
   AgaP_AGAP012301,  A.gambiae
AgaP_AGAP012301
    XP_320240.4
361 aa
   R04B3.2,  C.elegans
R04B3.2
    NP_508448.1
363 aa
   MGG_03346,  M.oryzae
MGG_03346
    XP_003716606.1
355 aa
   AT5G61540,  A.thaliana
AT5G61540
    NP_200962.2
359 aa
   Os04g0549300,  O.sativa
Os04g0549300
    NP_001053482.1
387 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Aspartylglucosaminuria.



Publications
Articles associated with genes and sequences of this homology group.

Expanding targets for a metabolic therapy of cancer: L-asparaginase.
Covini D, et al. Recent Pat Anticancer Drug Discov 7, 4-13 (2012).
Structural basis of aspartylglucosaminuria.
Saito S, et al. Biochem Biophys Res Commun 377, 1168-72 (2008).
Autoproteolytic activation of human aspartylglucosaminidase.
Saarela J, et al. Biochem J 378, 363-71 (2004).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Ntn_Asparaginase_2_like (cl00635)
  Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Aga includes H.sapiens AGA and R.norvegicus Aga.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (16 transcripts, 14 species)
Actinopterygii - bony fishes (9 transcripts, 9 species)
Ascidiacea - tunicates (4 transcripts, 3 species)
Amphibia - amphibians (3 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (13 transcripts, 13 species)
Arachnida - arachnids (2 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (2 transcripts, 1 species)
Hirudinida - segmented worms (2 transcripts, 1 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (19 transcripts, 17 species)
Liliopsida - monocots (11 transcripts, 6 species)
Coniferopsida - conifers (2 transcripts, 2 species)
Bryopsida - mosses (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (3 transcripts, 3 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

 

 

 

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