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HomoloGene:426. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   F2,  H.sapiens
coagulation factor II (thrombin)
    NP_000497.1
622 aa
   F2,  P.troglodytes
coagulation factor II (thrombin)
    XP_001165233.1
622 aa
   F2,  M.mulatta
coagulation factor II (thrombin)
    NP_001098055.1
627 aa
   F2,  C.lupus
coagulation factor II (thrombin)
    XP_003639742.1
621 aa
   F2,  B.taurus
coagulation factor II (thrombin)
    NP_776302.1
625 aa
   F2,  M.musculus
coagulation factor II
    NP_034298.1
618 aa
   F2,  R.norvegicus
coagulation factor II
    NP_075213.2
617 aa
   F2,  G.gallus
coagulation factor II (thrombin)
    NP_989936.1
607 aa
   f2,  X.tropicalis
coagulation factor 2 (thrombin)
    NP_001015797.1
607 aa
   f2,  D.rerio
coagulation factor II (thrombin)
    NP_998555.1
524 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Dysprothrombinemia.
Hyperprothrombinemia.
Hypoprothrombinemia.



Publications
Articles associated with genes and sequences of this homology group.

Congenital prothrombin deficiency: an update.
Lancellotti S, et al. Semin Thromb Hemost 39, 596-606 (2013).
Elevated prothrombin promotes venous, but not arterial, thrombosis in mice.
Aleman MM, et al. Arterioscler Thromb Vasc Biol 33, 1829-36 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Thrombin_light (pfam09396)
  Thrombin light chain.
Tryp_SPc (cd00190)
  Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Gla (cl02449)
  Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain.
KR (cl00100)
  Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus F2 includes H.sapiens F2 and R.norvegicus F2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (17 transcripts, 13 species)
Actinopterygii - bony fishes (14 transcripts, 10 species)
Amniota - vertebrates (2 transcripts, 1 species)
Aves - birds (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

 

 

 

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