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HomoloGene:191. Gene conserved in Tetrapoda Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   LAMB3,  H.sapiens
laminin, beta 3
1172 aa
   LAMB3,  P.troglodytes
laminin, beta 3
1171 aa
   LAMB3,  M.mulatta
laminin, beta 3
1174 aa
   LAMB3,  C.lupus
laminin, beta 3
1172 aa
   LAMB3,  B.taurus
laminin, beta 3
1172 aa
   Lamb3,  M.musculus
laminin, beta 3
1168 aa
   Lamb3,  R.norvegicus
laminin, beta 3
1172 aa
   LAMB3,  G.gallus
laminin, beta 3
1168 aa
   lamb3,  X.tropicalis
laminin, beta 3
1177 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Epidermolysis bullosa, generalized atrophic benign.
Epidermolysis bullosa, Herlitz junctional type.

Articles associated with genes and sequences of this homology group.

LAMB3 mutations causing autosomal-dominant amelogenesis imperfecta.
Kim JW, et al. J Dent Res 92, 899-904 (2013).
Histopathology of anti-laminin 5 mucous membrane pemphigoid.
Rose C, et al. J Am Acad Dermatol 61, 433-40 (2009).
Human laminin-332 degradation by Candida proteinases.
Pärnänen P, et al. J Oral Pathol Med 37, 329-35 (2008).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
MA (smart00283)
  Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).
Laminin_EGF (pfam00053)
  Laminin EGF-like (Domains III and V).
SpoVIF (pfam14069)
  Stage VI sporulation protein F.
SPEC (cd00176)
  Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
Laminin_N (cl02806)
  Laminin N-terminal (Domain VI).
Laminin_N (cl02806)
  Laminin N-terminal (Domain VI).
MCP_signal (cl19050)
  Methyl-accepting chemotaxis protein (MCP), signaling domain.
EGF_Lam (cl19065)
  Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Lamb3 includes H.sapiens LAMB3 and R.norvegicus Lamb3.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (9 transcripts, 8 species)

Hirudinida - segmented worms (1 transcript, 1 species)




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