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HomoloGene:4512. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   ORC2,  H.sapiens
origin recognition complex, subunit 2
    NP_006181.1
577 aa
   ORC2,  P.troglodytes
origin recognition complex, subunit 2
    XP_516023.3
577 aa
   LOC700691,  M.mulatta
origin recognition complex subunit 2-like
    XP_002808067.1
578 aa
   ORC2,  C.lupus
origin recognition complex, subunit 2
    XP_005640572.1
577 aa
   ORC2,  B.taurus
origin recognition complex, subunit 2
    NP_001095412.1
566 aa
   Orc2,  M.musculus
origin recognition complex, subunit 2
    NP_032791.1
576 aa
   Orc2,  R.norvegicus
origin recognition complex, subunit 2
    NP_001012003.1
576 aa
   ORC2,  G.gallus
origin recognition complex, subunit 2
    NP_001006517.1
569 aa
   orc2,  X.tropicalis
origin recognition complex, subunit 2
    NP_001072806.1
558 aa
   zgc:153041,  D.rerio
zgc:153041
    NP_001070772.1
553 aa
   Orc2,  D.melanogaster
Origin recognition complex subunit 2
    NP_731873.1
618 aa
   AgaP_AGAP000474,  A.gambiae
AgaP_AGAP000474
    XP_310617.4
682 aa
   ORC2,  A.thaliana
ORC2
    NP_181292.1
363 aa
   Os03g0184700,  O.sativa
Os03g0184700
    NP_001049192.1
379 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

D.melanogaster
Homozygous larvae contain rudimentary imaginal discs, but disc primordia do not grow during larval development; testes and ovaries smaller than normal and cell number in central nervous system reduced. Mutant gonads do not survive metamorphosis when implanted into wild-type larvae. Homozygous cuticular clones appear to develop normally, but abdominal clones reduced in frequency and size compared to control clones. Mutant larvae support growth of implanted wild-type discs. Normal gene product postulated to be required for cell proliferation; survival of somatic epidermal clones attributed to perdurance. (See FlyBase for complete description.)



Publications
Articles associated with genes and sequences of this homology group.

Think global, act local--how to regulate S phase from individual replication origins.
Pasero P & Schwob E. Curr Opin Genet Dev 10, 178-86 (2000).
Separation of origin recognition complex functions by cross-species complementation.
Ehrenhofer-Murray AE, et al. Science 270, 1671-4 (1995).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
ORC2 (pfam04084)
  Origin recognition complex subunit 2.
ORC2 (pfam04084)
  Origin recognition complex subunit 2.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Orc2 includes H.sapiens ORC2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (9 transcripts, 9 species)
Actinopterygii - bony fishes (7 transcripts, 7 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (6 transcripts, 5 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (18 transcripts, 16 species)
Liliopsida - monocots (7 transcripts, 7 species)
Coniferopsida - conifers (2 transcripts, 2 species)

Ascomycota
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

 

 

 

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