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HomoloGene:21010. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   ROCK2,  H.sapiens
Rho-associated, coiled-coil containing protein kinase 2
    NP_004841.2
1388 aa
   ROCK2,  P.troglodytes
Rho-associated, coiled-coil containing protein kinase 2
    XP_525689.3
1388 aa
   ROCK2,  M.mulatta
Rho-associated, coiled-coil containing protein kinase 2
    XP_001096931.2
1388 aa
   ROCK2,  C.lupus
Rho-associated, coiled-coil containing protein kinase 2
    XP_540083.4
1661 aa
   ROCK2,  B.taurus
Rho-associated, coiled-coil containing protein kinase 2
    NP_776877.1
1388 aa
   Rock2,  M.musculus
Rho-associated coiled-coil containing protein kinase 2
    NP_033098.2
1388 aa
   Rock2,  R.norvegicus
Rho-associated coiled-coil containing protein kinase 2
    NP_037154.2
1388 aa
   ROCK2,  G.gallus
Rho-associated, coiled-coil containing protein kinase 2
    XP_004935820.1
1383 aa
   rock2,  X.tropicalis
Rho-associated, coiled-coil containing protein kinase 2
    XP_004914525.1
1399 aa
   rock2a,  D.rerio
rho-associated, coiled-coil containing protein kinase 2a
    NP_777288.1
1375 aa
   rok,  D.melanogaster
Rho-kinase
    NP_536796.2
1390 aa
   AgaP_AGAP000406,  A.gambiae
AgaP_AGAP000406
    XP_310694.5
1394 aa
   let-502,  C.elegans
let-502
    NP_491440.1
1173 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Rho-kinase inhibition prevents proteinuria in immune-complex-mediated antipodocyte nephritis.
Meyer-Schwesinger C, et al. Am J Physiol Renal Physiol 303, F1015-25 (2012).
ROCKII Ser1366 phosphorylation reflects the activation status.
Chuang HH, et al. Biochem J 443, 145-51 (2012).
Regulation of ROCKII membrane localization through its C-terminus.
Kher SS & Worthylake RA. Exp Cell Res 317, 2845-52 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
V_Alix_like (cl14654)
  Protein-interacting V-domain of mammalian Alix and related domains.
Fzo_mitofusin (pfam04799)
  fzo-like conserved region.
PH-like (cl00273)
  Pleckstrin homology-like domain.
COG1579 (COG1579)
  Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only].
C1 (cl00040)
  Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
HR1 (cl00087)
  Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
PH-like (cl17171)
  Pleckstrin homology-like domain.
ApoLp-III_like (cl19113)
  Apolipophorin-III and similar insect proteins.
DUF342 (cl19219)
  Protein of unknown function (DUF342).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Rock2 includes H.sapiens ROCK2 and R.norvegicus Rock2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (23 transcripts, 9 species)
Mammalia - mammals (16 transcripts, 11 species)
Aves - birds (5 transcripts, 2 species)
Amphibia - amphibians (3 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (7 transcripts, 6 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

 

 

 

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