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HomoloGene:1645. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   IL6ST,  H.sapiens
interleukin 6 signal transducer (gp130, oncostatin M receptor)
    NP_002175.2
918 aa
   IL6ST,  P.troglodytes
interleukin 6 signal transducer (gp130, oncostatin M receptor)
    XP_001144416.1
918 aa
   IL6ST,  M.mulatta
interleukin 6 signal transducer (gp130, oncostatin M receptor)
    XP_001100601.1
918 aa
   IL6ST,  C.lupus
interleukin 6 signal transducer (gp130, oncostatin M receptor)
    XP_005617454.1
918 aa
   IL6ST,  B.taurus
interleukin 6 signal transducer (gp130, oncostatin M receptor)
    XP_002696368.3
918 aa
   Il6st,  M.musculus
interleukin 6 signal transducer
    NP_034690.3
917 aa
   Il6st,  R.norvegicus
interleukin 6 signal transducer
    NP_001008725.2
918 aa
   IL6ST,  G.gallus
interleukin 6 signal transducer (gp130, oncostatin M receptor)
    NP_990202.1
918 aa
   il6st,  X.tropicalis
interleukin 6 signal transducer (gp130, oncostatin M receptor)
    XP_002940276.2
892 aa
   il6st,  D.rerio
interleukin 6 signal transducer
    NP_001106976.1
866 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Glycoprotein 130 promotes human blastocyst development in vitro.
Hambiliki F, et al. Fertil Steril 99, 1592-9 (2013).
gp130 activation is regulated by D2-D3 interdomain connectivity.
Schütt A, et al. Biochem J 450, 487-96 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Lep_receptor_Ig (pfam06328)
  Ig-like C2-type domain.
IL6Ra-bind (cl12153)
  Interleukin-6 receptor alpha chain, binding.
EpoR_lig-bind (pfam09067)
  Erythropoietin receptor, ligand binding.
IL6Ra-bind (pfam09240)
  Interleukin-6 receptor alpha chain, binding.
Lep_receptor_Ig (pfam06328)
  Ig-like C2-type domain.
EpoR_lig-bind (pfam09067)
  Erythropoietin receptor, ligand binding.
FN3 (cl00065)
  Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Il6st includes H.sapiens IL6ST and R.norvegicus Il6st.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (17 transcripts, 12 species)
Actinopterygii - bony fishes (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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