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HomoloGene:88. Gene conserved in Amniota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   EDN3,  H.sapiens
endothelin 3
    NP_996915.1
219 aa
   EDN3,  P.troglodytes
endothelin 3
    XP_525373.2
219 aa
   EDN3,  C.lupus
endothelin 3
    NP_001002942.1
198 aa
   EDN3,  B.taurus
endothelin 3
    NP_001095449.1
271 aa
   Edn3,  M.musculus
endothelin 3
    NP_031929.1
214 aa
   Edn3,  R.norvegicus
endothelin 3
    NP_001071118.1
167 aa
   EDN3,  G.gallus
endothelin 3
    XP_001231488.3
251 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Hirschsprung disease.
Central hypoventilation syndrome, congenital.
Shah-Waardenburg syndrome.



Publications
Articles associated with genes and sequences of this homology group.

Endothelin-3 stimulates survival of goblet cells in organotypic cultures of fetal human colonic epithelium.
Kalabis J, et al. Am J Physiol Gastrointest Liver Physiol 295, G1182-9 (2008).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Endothelin (pfam00322)
  Endothelin family.
END (smart00272)
  Endothelin.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Edn3 includes H.sapiens EDN3 and R.norvegicus Edn3.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (7 transcripts, 7 species)
Actinopterygii - bony fishes (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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