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HomoloGene:7982. Gene conserved in Boreoeutheria Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   TREX1,  H.sapiens
three prime repair exonuclease 1
369 aa
   TREX1,  P.troglodytes
three prime repair exonuclease 1
369 aa
   LOC100429168,  M.mulatta
three prime repair exonuclease 1-like
474 aa
   TREX1,  C.lupus
three prime repair exonuclease 1
373 aa
   TREX1,  B.taurus
three prime repair exonuclease 1
315 aa
   Trex1,  M.musculus
three prime repair exonuclease 1
314 aa
   Trex1,  R.norvegicus
three prime repair exonuclease 1
316 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Aicardi-Goutieres syndrome 1.
Cree encephalitis.
Chilblain lupus.
Aicardi-Goutieres syndrome 5.

Articles associated with genes and sequences of this homology group.

The exonuclease Trex1 restrains macrophage proinflammatory activation.
Pereira-Lopes S, et al. J Immunol 191, 6128-35 (2013).
Systemic involvement in TREX1-associated familial chilblain lupus.
Günther C, et al. J Am Acad Dermatol 69, e179-81 (2013).
Heterozygous TREX1 mutations in early-onset cerebrovascular disease.
Pelzer N, et al. J Neurol 260, 2188-90 (2013).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
DnaQ_like_exo (cl10012)
  DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Trex1 includes H.sapiens TREX1.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (9 transcripts, 7 species)




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