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HomoloGene:55757. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PDHX,  H.sapiens
pyruvate dehydrogenase complex, component X
    NP_003468.2
501 aa
   PDHX,  P.troglodytes
pyruvate dehydrogenase complex, component X
    XP_001149489.1
501 aa
   PDHX,  M.mulatta
pyruvate dehydrogenase complex, component X
    XP_001109997.2
468 aa
   PDHX,  C.lupus
pyruvate dehydrogenase complex, component X
    XP_533153.2
501 aa
   LOC517402,  B.taurus
pyruvate dehydrogenase protein X component-like
    NP_001069219.1
501 aa
   Pdhx,  M.musculus
pyruvate dehydrogenase complex, component X
    NP_780303.1
501 aa
   PDHX,  G.gallus
pyruvate dehydrogenase complex, component X
    NP_001026358.1
502 aa
   pdhx,  X.tropicalis
pyruvate dehydrogenase complex, component X
    XP_002937341.2
459 aa
   pdhx,  D.rerio
pyruvate dehydrogenase complex, component X
    NP_956854.1
490 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Lacticacidemia due to PDX1 deficiency.



Publications
Articles associated with genes and sequences of this homology group.

Pyruvate dehydrogenase E3 binding protein (protein X) deficiency.
Brown RM, et al. Dev Med Child Neurol 48, 756-60 (2006).
Regulation of PDK mRNA by high fatty acid and glucose in pancreatic islets.
Xu J, et al. Biochem Biophys Res Commun 344, 827-33 (2006).
Leigh's disease due to a new mutation in the PDHX gene.
Schiff M, et al. Ann Neurol 59, 709-14 (2006).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
E3_binding (pfam02817)
  e3 binding domain.
2-oxoacid_dh (pfam00198)
  2-oxoacid dehydrogenases acyltransferase (catalytic domain).
PDHac_trf_mito (TIGR01349)
  pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form.
COG1615 (cl09133)
  Uncharacterized conserved protein [Function unknown].
2-oxoacid_dh (pfam00198)
  2-oxoacid dehydrogenases acyltransferase (catalytic domain).
E3_binding (pfam02817)
  e3 binding domain.
Biotinyl_lipoyl_domains (cl11404)
  Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl, ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Pdhx includes H.sapiens PDHX and R.norvegicus Pdhx.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (17 transcripts, 14 species)
Actinopterygii - bony fishes (12 transcripts, 10 species)
Ascidiacea - tunicates (4 transcripts, 3 species)
Aves - birds (4 transcripts, 2 species)
Amphibia - amphibians (3 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (3 transcripts, 3 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (1 transcript, 1 species)

Oomycetes
Pythiales - oomycetes (1 transcript, 1 species)

 

 

 

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