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HomoloGene:4392. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   TCIRG1,  H.sapiens
T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
    NP_006010.2
830 aa
   TCIRG1,  P.troglodytes
T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
    XP_522295.3
830 aa
   TCIRG1,  M.mulatta
T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
    XP_001103418.2
888 aa
   TCIRG1,  C.lupus
T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
    XP_540812.1
830 aa
   TCIRG1,  B.taurus
T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
    NP_001069102.1
830 aa
   Tcirg1,  M.musculus
T cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3
    NP_001129563.1
834 aa
   Tcirg1,  R.norvegicus
T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
    NP_954520.2
834 aa
   TCIRG1,  G.gallus
T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
    NP_990053.1
837 aa
   tcirg1,  X.tropicalis
T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
    NP_001016849.1
823 aa
   tcirg1,  D.rerio
T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
    XP_005160329.1
823 aa
   zgc:55891,  D.rerio
zgc:55891
    NP_998234.1
822 aa
   LOC100147923,  D.rerio
V-type proton ATPase 116 kDa subunit a isoform 3-like
    XP_001922910.4
793 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Osteopetrosis, recessive.



Publications
Articles associated with genes and sequences of this homology group.

Direct recruitment of H+-ATPase from lysosomes for phagosomal acidification.
Sun-Wada GH, et al. J Cell Sci 122, 2504-13 (2009).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
V_ATPase_I (pfam01496)
  V-type ATPase 116kDa subunit family.
V_ATPase_I (pfam01496)
  V-type ATPase 116kDa subunit family.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Tcirg1 includes H.sapiens TCIRG1 and R.norvegicus Tcirg1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (14 transcripts, 11 species)
Actinopterygii - bony fishes (7 transcripts, 6 species)
Amphibia - amphibians (4 transcripts, 2 species)
Ascidiacea - tunicates (3 transcripts, 2 species)
Aves - birds (2 transcripts, 1 species)

Arthropoda
Arachnida - arachnids (4 transcripts, 2 species)
Branchiopoda - crustaceans (3 transcripts, 1 species)
Insecta - insects (2 transcripts, 2 species)
Malacostraca - crustaceans (1 transcript, 1 species)

Platyhelminthes
Turbellaria - flatworms (4 transcripts, 1 species)

Cnidaria
Hydrozoa - hydrozoans (2 transcripts, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Streptophyta
Liliopsida - monocots (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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