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HomoloGene:526. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   ITGAM,  H.sapiens
integrin, alpha M (complement component 3 receptor 3 subunit)
    NP_001139280.1
1153 aa
   ITGAM,  P.troglodytes
integrin, alpha M (complement component 3 receptor 3 subunit)
    NP_001181863.1
1153 aa
   ITGAM,  C.lupus
integrin, alpha M (complement component 3 receptor 3 subunit)
    XP_848527.1
1153 aa
   ITGAM,  B.taurus
integrin, alpha M (complement component 3 receptor 3 subunit)
    NP_001035046.1
1152 aa
   Itgam,  M.musculus
integrin alpha M
    NP_001076429.1
1154 aa
   Itgam,  R.norvegicus
integrin, alpha M
    NP_036843.1
1151 aa
   itgad,  X.tropicalis
integrin, alpha D
    XP_004918207.1
1159 aa
   LOC100495489,  X.tropicalis
integrin alpha-M-like
    XP_002940816.2
1152 aa
   itgam,  X.tropicalis
integrin, alpha M (complement component 3 receptor 3 subunit)
    XP_004918403.1
1211 aa
   LOC563715,  D.rerio
integrin alpha-X-like
    XP_692164.5
1132 aa
   LOC101882585,  D.rerio
integrin alpha-X-like
    XP_005156064.1
1136 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Upregulation of CD11b on eosinophils in aspirin induced asthma.
Isogai S, et al. Allergol Int 62, 367-73 (2013).
The CD11b-integrin (ITGAM) and systemic lupus erythematosus.
Fagerholm SC, et al. Lupus 22, 657-63 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Integrin_alpha (pfam00357)
  Integrin alpha cytoplasmic region.
Integrin_alpha2 (pfam08441)
  Integrin alpha.
vWFA (cl00057)
  Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
FG-GAP (cl15299)
  FG-GAP repeat.
Integrin_alpha (pfam00357)
  Integrin alpha cytoplasmic region.
Integrin_alpha2 (pfam08441)
  Integrin alpha.
vWFA (cl00057)
  Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
VCBS (cl15299)
  This domain of about 100 residues is found in multiple (up to 35) copies in long proteins from several species of Vibrio, Colwellia, Bradyrhizobium, and Shewanella (hence the name VCBS) and in smaller copy numbers in proteins from several other bacteria. The large protein size and repeat copy numbers, species distribution, and suggested activities of several member proteins suggests a role for this domain in adhesion (TIGR).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Itgam includes H.sapiens ITGAM and R.norvegicus Itgam.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (7 transcripts, 7 species)

 

 

 

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