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HomoloGene:57028. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PCBD1,  H.sapiens
pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
    NP_000272.1
104 aa
   PCBD1,  P.troglodytes
pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
    XP_001171466.1
104 aa
   PCBD1,  M.mulatta
pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
    XP_001107537.1
104 aa
   PCBD1,  C.lupus
pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
    XP_005619043.1
107 aa
   PCBD1,  B.taurus
pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
    NP_001193403.1
104 aa
   Pcbd1,  M.musculus
pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 1
    NP_079549.1
104 aa
   Pcbd1,  R.norvegicus
pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
    NP_001007602.1
104 aa
   PCBD1,  G.gallus
pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
    NP_990236.1
104 aa
   pcbd1,  X.tropicalis
pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
    NP_001011016.1
104 aa
   pcbd1,  D.rerio
6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1)
    NP_957108.1
102 aa
   Pcd,  D.melanogaster
pterin-4a-carbinolamine dehydratase
    NP_477360.2
192 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Hyperphenylalaninemia due to pterin-4a-carbinolamine dehydratase deficiency.



Publications
Articles associated with genes and sequences of this homology group.

Regulation of the HNF-1 homeodomain proteins by DCoH.
Hansen LP & Crabtree GR. Curr Opin Genet Dev 3, 246-53 (1993).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PCD_DCoH (cl00942)
  PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Pcbd1 includes H.sapiens PCBD1 and R.norvegicus Pcbd1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (13 transcripts, 12 species)
Actinopterygii - bony fishes (10 transcripts, 9 species)
Amphibia - amphibians (3 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (5 transcripts, 5 species)
Maxillopoda - crustaceans (2 transcripts, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

 

 

 

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