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HomoloGene:88408. Gene conserved in Murinae Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   Prss1,  M.musculus
protease, serine 1 (trypsin 1)
246 aa
   Gm5771,  M.musculus
predicted gene 5771
245 aa
   Prss3,  M.musculus
protease, serine 3
246 aa
   Gm10334,  M.musculus
predicted gene 10334
246 aa
   Try10,  R.norvegicus
trypsin 10
246 aa
   LOC100912089,  R.norvegicus
anionic trypsin-2-like
246 aa
   Prss2,  R.norvegicus
protease, serine, 2
246 aa
   LOC683849,  R.norvegicus
similar to Anionic trypsin II precursor (Pretrypsinogen II)
246 aa
   LOC102554637,  R.norvegicus
anionic trypsin-2-like
246 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Activated microglia enhance neurogenesis via trypsinogen secretion.
Nikolakopoulou AM, et al. Proc Natl Acad Sci U S A 110, 8714-9 (2013).
Activation of trypsinogen in large endocytic vacuoles of pancreatic acinar cells.
Sherwood MW, et al. Proc Natl Acad Sci U S A 104, 5674-9 (2007).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Tryp_SPc (cd00190)
  Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Prss1 includes H.sapiens PRSS1 and R.norvegicus Prss1.
Orthology group for M.musculus Prss3 includes H.sapiens PRSS3.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Insecta - insects (13 transcripts, 6 species)
Branchiopoda - crustaceans (8 transcripts, 1 species)
Maxillopoda - crustaceans (4 transcripts, 1 species)

Mammalia - mammals (11 transcripts, 5 species)
Actinopterygii - bony fishes (8 transcripts, 4 species)
Cephalochordata - lancelets (5 transcripts, 1 species)

Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Turbellaria - flatworms (2 transcripts, 1 species)




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