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HomoloGene:48325. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   TRIM25,  H.sapiens
tripartite motif containing 25
630 aa
   TRIM25,  P.troglodytes
tripartite motif containing 25
630 aa
   LOC712588,  M.mulatta
e3 ubiquitin/ISG15 ligase TRIM25-like
750 aa
   TRIM25,  C.lupus
tripartite motif containing 25
631 aa
   TRIM25,  B.taurus
tripartite motif containing 25
631 aa
   Trim25,  M.musculus
tripartite motif-containing 25
634 aa
   Trim25,  R.norvegicus
tripartite motif-containing 25
643 aa
   TRIM25,  G.gallus
tripartite motif containing 25
672 aa
   trim25,  D.rerio
tripartite motif-containing 25
654 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Molecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domains.
Akutsu M, et al. Proc Natl Acad Sci U S A 108, 2228-33 (2011).
Systemic distribution of estrogen-responsive finger protein (Efp) in human tissues.
Shimada N, et al. Mol Cell Endocrinol 218, 147-53 (2004).
Estrogen-responsive RING finger protein controls breast cancer growth.
Horie K, et al. J Steroid Biochem Mol Biol 85, 101-4 (2003).
Molecular cloning of rat efp: expression and regulation in primary osteoblasts.
Inoue S, et al. Biochem Biophys Res Commun 261, 412-8 (1999).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
BBC (smart00502)
  B-Box C-terminal domain.
DegS (pfam05384)
  Sensor protein DegS.
zf-C3HC4_2 (pfam13923)
  Zinc finger, C3HC4 type (RING finger).
COG1340 (COG1340)
  Uncharacterized archaeal coiled-coil protein [Function unknown].
PspA (COG1842)
  Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms].
BBOX (cl00034)
  B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
HR1 (cl00087)
  Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases.
MttA_Hcf106 (cl00788)
  mttA/Hcf106 family.
SPRY (cl02614)
  SPRY domain.
PRY (cl02686)
  SPRY-associated domain.
Rifin_STEVOR (cl14106)
  Rifin/stevor family.
RING (cl17238)
  RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Trim25 includes H.sapiens TRIM25 and R.norvegicus Trim25.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Actinopterygii - bony fishes (7 transcripts, 6 species)
Mammalia - mammals (6 transcripts, 6 species)




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