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HomoloGene:55456. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   SLC5A1,  H.sapiens
solute carrier family 5 (sodium/glucose cotransporter), member 1
    NP_000334.1
664 aa
   SLC5A1,  P.troglodytes
solute carrier family 5 (sodium/glucose cotransporter), member 1
    XP_515093.3
664 aa
   SLC5A1,  M.mulatta
solute carrier family 5 (sodium/glucose cotransporter), member 1
    XP_001112212.1
663 aa
   SLC5A1,  C.lupus
solute carrier family 5 (sodium/glucose cotransporter), member 1
    NP_001007142.1
662 aa
   SLC5A1,  B.taurus
solute carrier family 5 (sodium/glucose cotransporter), member 1
    NP_777031.1
664 aa
   Slc5a1,  M.musculus
solute carrier family 5 (sodium/glucose cotransporter), member 1
    NP_062784.3
665 aa
   Slc5a1,  R.norvegicus
solute carrier family 5 (sodium/glucose cotransporter), member 1
    NP_037165.1
665 aa
   SLC5A1,  G.gallus
solute carrier family 5 (sodium/glucose cotransporter), member 1
    XP_415247.3
647 aa
   LOC100498135,  X.tropicalis
sodium/glucose cotransporter 1-like
    XP_002931963.2
657 aa
   LOC100493915,  X.tropicalis
sodium/glucose cotransporter 1-like
    XP_004910646.1
665 aa
   slc5a1,  D.rerio
solute carrier family 5 (sodium/glucose cotransporter), member 1
    NP_956975.1
658 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Glucose/galactose malabsorption.



Publications
Articles associated with genes and sequences of this homology group.

Functional identification and characterization of sodium binding sites in Na symporters.
Loo DD, et al. Proc Natl Acad Sci U S A 110, E4557-66 (2013).
Relevance of sodium/glucose cotransporter-1 (SGLT1) to diabetes mellitus and obesity in dogs.
Batchelor DJ, et al. Domest Anim Endocrinol 44, 139-44 (2013).
Bridging the gap between structure and kinetics of human SGLT1.
Sala-Rabanal M, et al. Am J Physiol Cell Physiol 302, C1293-305 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
SLC5-6-like_sbd (cl00456)
  Solute carrier families 5 and 6-like; solute binding domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Slc5a1 includes H.sapiens SLC5A1 and R.norvegicus Slc5a1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (14 transcripts, 12 species)
Actinopterygii - bony fishes (12 transcripts, 8 species)
Ascidiacea - tunicates (4 transcripts, 2 species)
Aves - birds (4 transcripts, 3 species)
Amphibia - amphibians (2 transcripts, 2 species)

Arthropoda
Arachnida - arachnids (1 transcript, 1 species)

Platyhelminthes
Turbellaria - flatworms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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