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HomoloGene:21202. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   MLLT4,  H.sapiens
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
    NP_001193937.1
1743 aa
   MLLT4,  P.troglodytes
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
    XP_518857.4
1781 aa
   MLLT4,  M.mulatta
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
    XP_001083153.1
1834 aa
   MLLT4,  C.lupus
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
    XP_005615632.1
1780 aa
   MLLT4,  B.taurus
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
    XP_005211198.1
1856 aa
   Mllt4,  M.musculus
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
    NP_034936.1
1820 aa
   Mllt4,  R.norvegicus
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
    NP_037349.1
1829 aa
   MLLT4,  G.gallus
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
    XP_004935593.1
1886 aa
   mllt4,  X.tropicalis
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
    XP_002931548.2
1752 aa
   mllt4,  D.rerio
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
    XP_686655.5
1892 aa
   afd-1,  C.elegans
afd-1
    NP_001021660.1
1419 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Afadin is required for maintenance of dendritic structure and excitatory tone.
Srivastava DP, et al. J Biol Chem 287, 35964-74 (2012).
Involvement of afadin in the formation and remodeling of synapses in the hippocampus.
Majima T, et al. Biochem Biophys Res Commun 385, 539-44 (2009).
Role of AF6 protein in cell-to-cell spread of Herpes simplex virus 1.
Keyser J, et al. FEBS Lett 581, 5349-54 (2007).
GeneSpeed: protein domain organization of the transcriptome.
Kutchma A, et al. Nucleic Acids Res 35, D674-9 (2007).
Nectin and afadin: novel organizers of intercellular junctions.
Takai Y & Nakanishi H. J Cell Sci 116, 17-27 (2003).
Ras target protein canoe is a substrate for Cdc2 and Cdk5 kinases.
Takahashi K, et al. Arch Insect Biochem Physiol 49, 102-7 (2002).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
DIL (pfam01843)
  DIL domain.
UBQ (cl00155)
  Ubiquitin-like proteins.
DIL (pfam01843)
  DIL domain.
CCDC50_N (pfam15295)
  Coiled-coil domain-containing protein 50 N-terminus.
FHA (cl00062)
  Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. Members of the FHA family include: Dun1, Rad53, Cds1, Mek1, KAPP(kinase-associated protein phosphatase),and Ki-67 (a human nuclear protein related to cell proliferation).
PDZ (cl00117)
  PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
UBQ (cl00155)
  Ubiquitin-like proteins.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Mllt4 includes H.sapiens MLLT4 and R.norvegicus Mllt4.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (15 transcripts, 9 species)
Actinopterygii - bony fishes (14 transcripts, 6 species)
Aves - birds (5 transcripts, 1 species)
Amphibia - amphibians (5 transcripts, 2 species)
Amniota - vertebrates (2 transcripts, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)

Arthropoda
Insecta - insects (9 transcripts, 7 species)
Arachnida - arachnids (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (3 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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