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HomoloGene:55429. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   CDK4,  H.sapiens
cyclin-dependent kinase 4
    NP_000066.1
303 aa
   CDK4,  P.troglodytes
cyclin-dependent kinase 4
    XP_509173.2
303 aa
   CDK4,  M.mulatta
cyclin-dependent kinase 4
    XP_001116422.1
303 aa
   CDK4,  C.lupus
cyclin-dependent kinase 4
    XP_849873.1
303 aa
   CDK4,  B.taurus
cyclin-dependent kinase 4
    NP_001032683.1
303 aa
   Cdk4,  M.musculus
cyclin-dependent kinase 4
    NP_034000.1
303 aa
   Cdk4,  R.norvegicus
cyclin-dependent kinase 4
    NP_446045.1
303 aa
   cdk4,  X.tropicalis
cyclin-dependent kinase 4
    NP_001016742.1
319 aa
   cdk4,  D.rerio
cyclin-dependent kinase 4
    NP_001071245.1
297 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Melanoma.



Publications
Articles associated with genes and sequences of this homology group.

CDK4: A Key Player in the Cell Cycle, Development, and Cancer.
Baker SJ & Reddy EP. Genes Cancer 3, 658-69 (2012).
Short communication: adhesion pathways utilized by HIV-infected lymphocytes.
Chow YH, et al. AIDS Res Hum Retroviruses 28, 1557-60 (2012).
Elevated expression of CDK4 in lung cancer.
Wu A, et al. J Transl Med 9, 38 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Cdk4 includes H.sapiens CDK4 and R.norvegicus Cdk4.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (19 transcripts, 15 species)
Actinopterygii - bony fishes (11 transcripts, 8 species)
Amphibia - amphibians (3 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (1 transcript, 1 species)
Arachnida - arachnids (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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