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HomoloGene:3638. Gene conserved in Tetrapoda Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   NR5A1,  H.sapiens
nuclear receptor subfamily 5, group A, member 1
    NP_004950.2
461 aa
   NR5A1,  P.troglodytes
nuclear receptor subfamily 5, group A, member 1
    XP_520248.3
652 aa
   NR5A1,  M.mulatta
nuclear receptor subfamily 5, group A, member 1
    XP_002800023.1
538 aa
   LOC609642,  C.lupus
nuclear receptor subfamily 6 group A member 1-like
    XP_005625439.1
466 aa
   NR5A1,  B.taurus
nuclear receptor subfamily 5, group A, member 1
    NP_776828.1
461 aa
   Nr5a1,  M.musculus
nuclear receptor subfamily 5, group A, member 1
    NP_620639.1
462 aa
   Nr5a1,  R.norvegicus
nuclear receptor subfamily 5, group A, member 1
    NP_001178028.1
462 aa
   NR5A1,  G.gallus
nuclear receptor subfamily 5, group A, member 1
    NP_990408.1
466 aa
   nr5a1,  X.tropicalis
nuclear receptor subfamily 5, group A, member 1
    NP_001139213.1
468 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Adrenocortical insufficiency without ovarian defect.
Sex reversal, XY, with adrenal failure.



Publications
Articles associated with genes and sequences of this homology group.

NR5A1 (SF-1) mutations are not a major cause of primary ovarian insufficiency.
Voican A, et al. J Clin Endocrinol Metab 98, E1017-21 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
IER (pfam05760)
  Immediate early response protein (IER).
NR_DBD_like (cl02596)
  DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers.
NR_LBD (cl11397)
  The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Nr5a1 includes H.sapiens NR5A1 and R.norvegicus Nr5a1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (11 transcripts, 10 species)
Actinopterygii - bony fishes (6 transcripts, 5 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

 

 

 

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