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HomoloGene:68446. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   ACTC1,  H.sapiens
actin, alpha, cardiac muscle 1
    NP_005150.1
377 aa
   ACTC1,  P.troglodytes
actin, alpha, cardiac muscle 1
    XP_510285.1
377 aa
   ACTC1,  M.mulatta
actin, alpha, cardiac muscle 1
    XP_001088409.2
381 aa
   ACTC1,  C.lupus
actin, alpha, cardiac muscle 1
    XP_535424.1
377 aa
   ACTC1,  B.taurus
actin, alpha, cardiac muscle 1
    NP_001029757.1
377 aa
   Actc1,  M.musculus
actin, alpha, cardiac muscle 1
    NP_033738.1
377 aa
   Actc1,  R.norvegicus
actin, alpha, cardiac muscle 1
    NP_062056.1
377 aa
   ACTC1,  G.gallus
actin, alpha, cardiac muscle 1
    NP_001072949.1
377 aa
   actc1,  X.tropicalis
actin, alpha, cardiac muscle 1
    NP_989094.1
377 aa
   actc1a,  D.rerio
actin, alpha, cardiac muscle 1a
    NP_001001409.2
377 aa
   hm:zewp0073,  D.rerio
hm:zewp0073
    XP_002665778.1
377 aa
   zgc:86709,  D.rerio
zgc:86709
    NP_001002066.1
377 aa
   actc1b,  D.rerio
actin, alpha, cardiac muscle 1b
    NP_571666.1
377 aa
   ACT7,  A.thaliana
ACT7
    NP_196543.1
377 aa
   Os11g0163100,  O.sativa
Os11g0163100
    NP_001065830.1
377 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Cardiomyopathy, dilated, 1R.
Cardiomyopathy, familial hypertrophic.



Publications
Articles associated with genes and sequences of this homology group.

Functional effects of nemaline myopathy mutations on human skeletal alpha-actin.
Miller BM & Trybus KM. J Biol Chem 283, 19379-88 (2008).
Alpha-cardiac actin mutations produce atrial septal defects.
Matsson H, et al. Hum Mol Genet 17, 256-65 (2008).
Overexpression of cardiac actin with baculovirus is promoter dependent.
Yates SP, et al. Arch Biochem Biophys 466, 58-65 (2007).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
NBD_sugar-kinase_HSP70_actin (cl17037)
  Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Actc1 includes H.sapiens ACTC1 and R.norvegicus Actc1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (71 transcripts, 12 species)
Mammalia - mammals (32 transcripts, 14 species)
Ascidiacea - tunicates (17 transcripts, 3 species)
Cephalochordata - lancelets (16 transcripts, 1 species)
Amphibia - amphibians (16 transcripts, 2 species)
Aves - birds (6 transcripts, 3 species)
Amniota - vertebrates (3 transcripts, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (7 transcripts, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Arthropoda
Insecta - insects (3 transcripts, 3 species)
Malacostraca - crustaceans (2 transcripts, 1 species)

Platyhelminthes
Trematoda - flatworms (4 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (83 transcripts, 32 species)
Liliopsida - monocots (28 transcripts, 9 species)
Coniferopsida - conifers (12 transcripts, 3 species)
Bryopsida - mosses (5 transcripts, 1 species)
Isoetopsida - club-mosses (2 transcripts, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (5 transcripts, 1 species)

Ciliophora
Oligohymenophorea - ciliates (1 transcript, 1 species)

 

 

 

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