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HomoloGene:20097. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   MUT,  H.sapiens
methylmalonyl CoA mutase
    NP_000246.2
750 aa
   MUT,  P.troglodytes
methylmalonyl CoA mutase
    XP_001146876.1
750 aa
   MUT,  M.mulatta
methylmalonyl CoA mutase
    XP_001104531.1
750 aa
   MUT,  C.lupus
methylmalonyl CoA mutase
    XP_532164.3
750 aa
   MUT,  B.taurus
methylmalonyl CoA mutase
    NP_776364.2
750 aa
   Mut,  M.musculus
methylmalonyl-Coenzyme A mutase
    NP_032676.2
748 aa
   Mut,  R.norvegicus
methylmalonyl CoA mutase
    XP_006244706.1
748 aa
   MUT,  G.gallus
methylmalonyl CoA mutase
    XP_004935974.1
810 aa
   mut,  X.tropicalis
methylmalonyl CoA mutase
    XP_004915010.1
758 aa
   mut,  D.rerio
methylmalonyl Coenzyme A mutase
    NP_001092696.1
757 aa
   mmcm-1,  C.elegans
mmcm-1
    NP_497786.2
744 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Methylmalonic aciduria, muttype.



Publications
Articles associated with genes and sequences of this homology group.

Mouse models for methylmalonic aciduria.
Peters HL, et al. PLoS One 7, e40609 (2012).
[Analysis of the MUT gene mutations in patients with methylmalonic acidemia].
Wang F, et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 26, 485-9 (2009).
Brain damage by mild metabolic derangements in methylmalonic acidemia.
Lee NC, et al. Pediatr Neurol 39, 325-9 (2008).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
MM_CoA_mutase (cl00817)
  Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of ...
B12-binding_like (cl00293)
  B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase, ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Mut includes H.sapiens MUT and R.norvegicus Mut.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (26 transcripts, 17 species)
Actinopterygii - bony fishes (15 transcripts, 9 species)
Ascidiacea - tunicates (3 transcripts, 2 species)
Amphibia - amphibians (3 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (3 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (2 transcripts, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (3 transcripts, 2 species)

Arthropoda
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Platyhelminthes
Turbellaria - flatworms (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Oomycetes
Pythiales - oomycetes (2 transcripts, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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