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HomoloGene:69065. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

FGFR1,  H.sapiens
fibroblast growth factor receptor 1
NP_001167538.1
853 aa
FGFR1,  P.troglodytes
fibroblast growth factor receptor 1
XP_001171131.1
821 aa
FGFR1,  C.lupus
fibroblast growth factor receptor 1
XP_005629905.1
822 aa
FGFR1,  B.taurus
fibroblast growth factor receptor 1
NP_001103677.1
820 aa
Fgfr1,  M.musculus
fibroblast growth factor receptor 1
NP_034336.2
822 aa
Fgfr1,  R.norvegicus
Fibroblast growth factor receptor 1
NP_077060.1
822 aa
FGFR1,  G.gallus
fibroblast growth factor receptor 1
NP_990841.1
819 aa
fgfr1,  X.tropicalis
fibroblast growth factor receptor 1
NP_001015894.1
814 aa
fgfr1a,  D.rerio
fibroblast growth factor receptor 1a
NP_694494.1
806 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Pfeiffer syndrome.
Jackson-Weiss syndrome.
Kallmann syndrome 2.



Publications
Articles associated with genes and sequences of this homology group.

FGFR1 is essential for prostate cancer progression and metastasis.
Yang F, et al. Cancer Res 73, 3716-24 (2013).
FGFR1 amplification in squamous cell carcinoma of the lung.
Heist RS, et al. J Thorac Oncol 7, 1775-80 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
Ig (cl11960)
  Immunoglobulin domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Fgfr1 includes H.sapiens FGFR1 and R.norvegicus Fgfr1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (14 transcripts, 11 species)
Actinopterygii - bony fishes (11 transcripts, 9 species)
Amphibia - amphibians (4 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (2 transcripts, 1 species)
Hydrozoa - hydrozoans (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (2 transcripts, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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