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HomoloGene:4892. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   MITF,  H.sapiens
microphthalmia-associated transcription factor
    NP_937802.1
520 aa
   MITF,  P.troglodytes
microphthalmia-associated transcription factor
    XP_001138876.1
520 aa
   MITF,  M.mulatta
microphthalmia-associated transcription factor
    XP_001086496.1
520 aa
   MITF,  C.lupus
microphthalmia-associated transcription factor
    NP_001003337.1
419 aa
   MITF,  B.taurus
microphthalmia-associated transcription factor
    NP_001001150.1
413 aa
   Mitf,  M.musculus
microphthalmia-associated transcription factor
    NP_001106669.1
526 aa
   Mitf,  R.norvegicus
microphthalmia-associated transcription factor
    NP_001178018.1
526 aa
   MITF,  G.gallus
microphthalmia-associated transcription factor
    NP_990360.1
468 aa
   mitf,  X.tropicalis
microphthalmia-associated transcription factor
    NP_001093747.1
483 aa
   mitfb,  D.rerio
microphthalmia-associated transcription factor b
    NP_571922.2
500 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Waardenburg syndrome/ocular albinism, digenic.
Tietz syndrome.
Waardenburg syndrome, type IIA.



Publications
Articles associated with genes and sequences of this homology group.




Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
DUF3371 (pfam11851)
  Domain of unknown function (DUF3371).
DUF3371 (pfam11851)
  Domain of unknown function (DUF3371).
HLH (cl00081)
  Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Mitf includes H.sapiens MITF and R.norvegicus Mitf.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (16 transcripts, 11 species)
Actinopterygii - bony fishes (5 transcripts, 4 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 1 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)

Arthropoda
Insecta - insects (3 transcripts, 3 species)

Echinodermata
Echinoidea - sea urchins (3 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

 

 

 

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