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HomoloGene:294. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   SOX9,  H.sapiens
SRY (sex determining region Y)-box 9
    NP_000337.1
509 aa
   SOX9,  P.troglodytes
SRY (sex determining region Y)-box 9
    NP_001009029.1
509 aa
   SOX9,  M.mulatta
SRY (sex determining region Y)-box 9
    NP_001028040.1
509 aa
   SOX9,  C.lupus
SRY (sex determining region Y)-box 9
    NP_001002978.1
513 aa
   SOX9,  B.taurus
SRY (sex determining region Y)-box 9
    XP_005221394.1
268 aa
   Sox9,  M.musculus
SRY (sex determining region Y)-box 9
    NP_035578.3
507 aa
   Sox9,  R.norvegicus
SRY (sex determining region Y)-box 9
    XP_003750998.1
507 aa
   SOX9,  G.gallus
SRY (sex determining region Y)-box 9
    NP_989612.1
494 aa
   sox9,  X.tropicalis
SRY (sex determining region Y)-box 9
    NP_001016853.1
482 aa
   sox9a,  D.rerio
SRY-box containing gene 9a
    NP_571718.1
462 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Acampomelic campomelic dysplasia.
Campomelic dysplasia.
Campomelic dysplasia with autosomal sex reversal.



Publications
Articles associated with genes and sequences of this homology group.

Sox9 plays multiple roles in the lung epithelium during branching morphogenesis.
Rockich BE, et al. Proc Natl Acad Sci U S A 110, E4456-64 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Sox_N (pfam12444)
  Sox developmental protein N terminal.
HMG-box (cl00082)
  High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
Sox_N (pfam12444)
  Sox developmental protein N terminal.
HMG-box (cl00082)
  High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Sox9 includes H.sapiens SOX9.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (16 transcripts, 12 species)
Actinopterygii - bony fishes (14 transcripts, 8 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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