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HomoloGene:106. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   F9,  H.sapiens
coagulation factor IX
    NP_000124.1
461 aa
   F9,  P.troglodytes
coagulation factor IX
    NP_001129063.1
461 aa
   F9,  M.mulatta
coagulation factor IX
    NP_001103153.1
461 aa
   F9,  C.lupus
coagulation factor IX
    NP_001003323.1
452 aa
   F9,  M.musculus
coagulation factor IX
    NP_032005.1
471 aa
   F9,  R.norvegicus
coagulation factor IX
    NP_113728.1
462 aa
   F9,  G.gallus
coagulation factor IX
    NP_989674.1
471 aa
   f9,  X.tropicalis
coagulation factor 9
    NP_001011223.1
463 aa
   f9b,  D.rerio
coagulation factor IXb
    NP_001035400.1
507 aa
   f9a,  D.rerio
coagulation factor IXa
    NP_878288.1
503 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Hemophilia B.
Warfarin sensitivity.



Publications
Articles associated with genes and sequences of this homology group.

Robust ZFN-mediated genome editing in adult hemophilic mice.
Anguela XM, et al. Blood 122, 3283-7 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Tryp_SPc (cd00190)
  Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
vWFA (cl00057)
  Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
Gla (cl02449)
  Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain.
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus F9 includes H.sapiens F9 and R.norvegicus F9.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (9 transcripts, 9 species)
Actinopterygii - bony fishes (8 transcripts, 7 species)
Aves - birds (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (10 transcripts, 9 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

 

 

 

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