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HomoloGene:85. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   DPYD,  H.sapiens
dihydropyrimidine dehydrogenase
    NP_000101.2
1025 aa
   DPYD,  P.troglodytes
dihydropyrimidine dehydrogenase
    XP_513583.3
1025 aa
   DPYD,  M.mulatta
dihydropyrimidine dehydrogenase
    XP_001106007.1
1025 aa
   DPYD,  C.lupus
dihydropyrimidine dehydrogenase
    XP_005621932.1
1000 aa
   DPYD,  B.taurus
dihydropyrimidine dehydrogenase
    NP_776466.1
1025 aa
   Dpyd,  M.musculus
dihydropyrimidine dehydrogenase
    NP_740748.1
1025 aa
   Dpyd,  R.norvegicus
dihydropyrimidine dehydrogenase
    NP_112289.1
1025 aa
   DPYD,  G.gallus
dihydropyrimidine dehydrogenase
    XP_426639.3
1025 aa
   dpyd,  X.tropicalis
dihydropyrimidine dehydrogenase
    XP_002933845.2
1025 aa
   dpydb,  D.rerio
dihydropyrimidine dehydrogenase b
    NP_998058.1
1022 aa
   su(r),  D.melanogaster
suppressor of rudimentary
    NP_572538.1
1031 aa
   AgaP_AGAP001021,  A.gambiae
AgaP_AGAP001021
    XP_003437170.1
1039 aa
   dpyd-1,  C.elegans
dpyd-1
    NP_508927.2
1059 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Fluorouracil toxicity, sensitivity to.
Thymine-uraciluria.



Publications
Articles associated with genes and sequences of this homology group.




Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Fer4_10 (pfam13237)
  4Fe-4S dicluster domain.
NAD_binding_8 (pfam13450)
  NAD(P)-binding Rossmann-like domain.
COG1144 (COG1144)
  Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit [Energy production and conversion]
TIM_phosphate_binding (cl17186)
  TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate ...
HCP_like (cl19102)
  The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved ...
NAD_binding_8 (cl19134)
  NAD(P)-binding Rossmann-like domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Dpyd includes H.sapiens DPYD and R.norvegicus Dpyd.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (24 transcripts, 9 species)
Mammalia - mammals (14 transcripts, 13 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (16 transcripts, 11 species)
Arachnida - arachnids (5 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Porifera
Demospongiae - sponges (2 transcripts, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Platyhelminthes
Turbellaria - flatworms (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (39 transcripts, 31 species)
Liliopsida - monocots (9 transcripts, 9 species)
Coniferopsida - conifers (3 transcripts, 3 species)
Bryopsida - mosses (2 transcripts, 1 species)
Isoetopsida - club-mosses (1 transcript, 1 species)

Chlorophyta
Chlorophyceae - green algae (2 transcripts, 2 species)

Dictyosteliida
Dictyostelium - cellular slime molds (1 transcript, 1 species)

 

 

 

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