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HomoloGene:1170. Gene conserved in Tetrapoda Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   HGFAC,  H.sapiens
HGF activator
    NP_001519.1
655 aa
   HGFAC,  P.troglodytes
HGF activator
    XP_001174601.2
655 aa
   HGFAC,  M.mulatta
HGF activator
    XP_001114822.2
620 aa
   HGFAC,  C.lupus
HGF activator
    NP_001026985.1
654 aa
   HGFAC,  B.taurus
HGF activator
    NP_001193958.1
651 aa
   Hgfac,  M.musculus
hepatocyte growth factor activator
    NP_062320.2
653 aa
   Hgfac,  R.norvegicus
HGF activator
    NP_445772.1
653 aa
   HGFAC,  G.gallus
HGF activator
    XP_420819.4
583 aa
   hgfac,  X.tropicalis
HGF activator
    XP_002939269.2
634 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Loss of HGF activator inhibits foveolar hyperplasia induced by oxyntic atrophy without altering gastrin levels.
Yamagata Y, et al. Am J Physiol Gastrointest Liver Physiol 303, G1254-61 (2012).
Changes in gene expression during progression of ovarian carcinoma.
Tapper J, et al. Cancer Genet Cytogenet 128, 1-6 (2001).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Tryp_SPc (cd00190)
  Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
NUT_N (pfam12881)
  NUT protein N terminus.
FN1 (cl00063)
  Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.
KR (cl00100)
  Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
FN2 (cl09951)
  Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Hgfac includes H.sapiens HGFAC and R.norvegicus Hgfac.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (8 transcripts, 7 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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