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HomoloGene:20108. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   RPE65,  H.sapiens
retinal pigment epithelium-specific protein 65kDa
    NP_000320.1
533 aa
   RPE65,  P.troglodytes
retinal pigment epithelium-specific protein 65kDa
    XP_001165086.1
550 aa
   RPE65,  M.mulatta
retinal pigment epithelium-specific protein 65kDa
    XP_001095946.1
533 aa
   RPE65,  C.lupus
retinal pigment epithelium-specific protein 65kDa
    NP_001003176.1
533 aa
   RPE65,  B.taurus
retinal pigment epithelium-specific protein 65kDa
    NP_776878.1
533 aa
   Rpe65,  M.musculus
retinal pigment epithelium 65
    NP_084263.2
533 aa
   Rpe65,  R.norvegicus
retinal pigment epithelium 65
    NP_446014.2
533 aa
   RPE65,  G.gallus
retinal pigment epithelium-specific protein 65kDa
    NP_990215.1
533 aa
   rpe65,  X.tropicalis
retinal pigment epithelium-specific protein 65kDa
    NP_001120538.1
533 aa
   rpe65b,  D.rerio
retinal pigment epithelium-specific protein 65b
    NP_001082902.2
532 aa
   rpe65a,  D.rerio
retinal pigment epithelium-specific protein 65a
    NP_957045.1
531 aa
   rpe65c,  D.rerio
retinal pigment epithelium-specific protein 65c
    NP_001107125.1
532 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Retinitis pigmentosa-20.
Leber congenital amaurosis-2.



Publications
Articles associated with genes and sequences of this homology group.

Complementation test of Rpe65 knockout and tvrm148.
Wright CB, et al. Invest Ophthalmol Vis Sci 54, 5111-22 (2013).
RPE65 gene therapy slows cone loss in Rpe65-deficient dogs.
Mowat FM, et al. Gene Ther 20, 545-55 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
RPE65 (pfam03055)
  Retinal pigment epithelial membrane protein.
RPE65 (cl10080)
  Retinal pigment epithelial membrane protein.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Rpe65 includes H.sapiens RPE65 and R.norvegicus Rpe65.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (14 transcripts, 7 species)
Mammalia - mammals (10 transcripts, 9 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)

Arthropoda
Insecta - insects (7 transcripts, 7 species)
Arachnida - arachnids (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Streptophyta
Liliopsida - monocots (4 transcripts, 4 species)
Eudicotyledons - eudicots (1 transcript, 1 species)

 

 

 

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