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HomoloGene:6820. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   LTA4H,  H.sapiens
leukotriene A4 hydrolase
    NP_000886.1
611 aa
   LTA4H,  P.troglodytes
leukotriene A4 hydrolase
    XP_001145972.1
611 aa
   LTA4H,  M.mulatta
leukotriene A-4 hydrolase-like
    XP_002808035.1
611 aa
   LTA4H,  C.lupus
leukotriene A4 hydrolase
    XP_539728.3
611 aa
   LTA4H,  B.taurus
leukotriene A4 hydrolase
    NP_001029452.1
611 aa
   Lta4h,  M.musculus
leukotriene A4 hydrolase
    NP_032543.2
611 aa
   Lta4h,  R.norvegicus
leukotriene A4 hydrolase
    NP_001025202.1
611 aa
   LTA4H,  G.gallus
leukotriene A4 hydrolase
    NP_001006234.1
612 aa
   lta4h,  X.tropicalis
leukotriene A4 hydrolase
    NP_001006898.1
609 aa
   lta4h,  D.rerio
leukotriene A4 hydrolase
    NP_998451.1
611 aa
   CG10602,  D.melanogaster
CG10602
    NP_609916.4
613 aa
   AgaP_AGAP009907,  A.gambiae
AgaP_AGAP009907
    XP_319027.4
646 aa
   ZC416.6,  C.elegans
ZC416.6
    NP_500385.1
625 aa
   C42C1.11,  C.elegans
C42C1.11
    NP_001023056.1
609 aa
   LAP2,  S.cerevisiae
LAP2
    NP_014353.1
671 aa
   KLLA0F03883g,  K.lactis
KLLA0F03883g
    XP_455256.1
662 aa
   SPCC1322.05c,  S.pombe
SPCC1322.05c
    NP_588133.1
612 aa
   MGG_09481,  M.oryzae
MGG_09481
    XP_003712268.1
660 aa
   NCU06732,  N.crassa
NCU06732
    XP_960660.1
614 aa
   AT5G13520,  A.thaliana
AT5G13520
    NP_196856.1
616 aa
   Os03g0819100,  O.sativa
Os03g0819100
    NP_001051710.1
611 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Leukotriene A4 hydrolase haplotype, diet and atherosclerosis: a twin study.
Zhao J, et al. Atherosclerosis 226, 238-44 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Leuk-A4-hydro_C (pfam09127)
  Leukotriene A4 hydrolase, C-terminal.
Leuk-A4-hydro_C (pfam09127)
  Leukotriene A4 hydrolase, C-terminal.
GluZincin (cl14813)
  Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Lta4h includes H.sapiens LTA4H and R.norvegicus Lta4h.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (20 transcripts, 15 species)
Actinopterygii - bony fishes (12 transcripts, 11 species)
Ascidiacea - tunicates (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)

Arthropoda
Insecta - insects (16 transcripts, 12 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (4 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (6 transcripts, 3 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (1 transcript, 1 species)
Liliopsida - monocots (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (1 transcript, 1 species)

 

 

 

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