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HomoloGene:36182. Gene conserved in Amniota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   KRT6A,  H.sapiens
keratin 6A
    NP_005545.1
564 aa
   KRT6A,  P.troglodytes
keratin 6A
    XP_509078.2
564 aa
   LOC100424162,  M.mulatta
keratin, type II cytoskeletal 6A-like
    XP_002798640.1
564 aa
   KRT6B,  C.lupus
keratin 6B
    XP_003433560.1
570 aa
   KRT6A,  C.lupus
keratin 6A
    XP_005636851.1
570 aa
   KRT6A,  B.taurus
keratin 6A
    NP_001076979.1
571 aa
   KRT6B,  B.taurus
keratin 6B
    NP_001244333.1
571 aa
   KRT6C,  B.taurus
keratin 6C
    XP_002687296.1
571 aa
   KRT3,  G.gallus
keratin 3
    XP_004949798.1
572 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Pachyonychia congenita, Jadassohn-Lewandowsky type.



Publications
Articles associated with genes and sequences of this homology group.

Pachyonychia congenita with laryngeal obstruction.
Haber RM & Drummond D. Pediatr Dermatol 28, 429-32 (2011).
[Keratin k6c mutations in focal palmoplantar keratoderma].
Dereure O. Ann Dermatol Venereol 137, 423-4 (2010).
[The 521 T--> C mutation in the keratin 6A gene in a pedigree with pachyonychia congenita type I].
Yang L, et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 27, 66-8 (2010).
[Two mutations of the KRT6A gene in Chinese patients with pachyonychia congenita type I].
Bai ZL, et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 26, 514-7 (2009).
Delayed wound healing in keratin 6a knockout mice.
Wojcik SM, et al. Mol Cell Biol 20, 5248-55 (2000).
Mutation of a type II keratin gene (K6a) in pachyonychia congenita.
Bowden PE, et al. Nat Genet 10, 363-5 (1995).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Filament (pfam00038)
  Intermediate filament protein.
DUF883 (cl01888)
  Bacterial protein of unknown function (DUF883).
ApoLp-III_like (cl19113)
  Apolipophorin-III and similar insect proteins.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (13 transcripts, 9 species)
Amphibia - amphibians (3 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

 

 

 

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