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HomoloGene:37277. Gene conserved in Opisthokonta Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   LIPA,  H.sapiens
lipase A, lysosomal acid, cholesterol esterase
    NP_001121077.1
399 aa
   LIPA,  P.troglodytes
lipase A, lysosomal acid, cholesterol esterase
    XP_003312800.1
399 aa
   LIPA,  M.mulatta
lipase A, lysosomal acid, cholesterol esterase
    XP_001085160.2
409 aa
   LIPA,  C.lupus
lipase A, lysosomal acid, cholesterol esterase
    XP_005636708.1
405 aa
   LIPA,  B.taurus
lipase A, lysosomal acid, cholesterol esterase
    NP_001096793.1
399 aa
   Lipa,  M.musculus
lysosomal acid lipase A
    NP_067435.3
397 aa
   Lipa,  R.norvegicus
lipase A, lysosomal acid, cholesterol esterase
    NP_036864.3
397 aa
   LIPA,  G.gallus
lipase A, lysosomal acid, cholesterol esterase (Wolman disease)
    XP_421661.3
398 aa
   lipa,  X.tropicalis
lipase A, lysosomal acid, cholesterol esterase
    NP_001015847.2
409 aa
   lipf,  D.rerio
lipase, gastric
    NP_998569.1
396 aa
   AgaP_AGAP001652,  A.gambiae
AgaP_AGAP001652
    XP_321444.5
527 aa
   lipl-1,  C.elegans
lipl-1
    NP_506229.1
405 aa
   lipl-7,  C.elegans
lipl-7
    NP_501877.2
409 aa
   lipl-4,  C.elegans
lipl-4
    NP_504662.1
411 aa
   lipl-5,  C.elegans
lipl-5
    NP_503184.1
403 aa
   lipl-3,  C.elegans
lipl-3
    NP_503233.1
404 aa
   lipl-6,  C.elegans
lipl-6
    NP_504755.2
562 aa
   lipl-2,  C.elegans
lipl-2
    NP_505527.1
411 aa
   TGL1,  S.cerevisiae
TGL1
    NP_012782.1
548 aa
   AGOS_AFR206C,  E.gossypii
AGOS_AFR206C
    NP_985753.1
442 aa
   SPCC1672.09,  S.pombe
SPCC1672.09
    NP_587880.1
467 aa
   MGG_02622,  M.oryzae
MGG_02622
    XP_003721170.1
613 aa
   NCU02148,  N.crassa
NCU02148
    XP_964507.2
609 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Cholesteryl ester storage disease.
Wolman disease.



Publications
Articles associated with genes and sequences of this homology group.

Lysosomal acid lipase A and the hypercholesterolaemic phenotype.
Fouchier SW & Defesche JC. Curr Opin Lipidol 24, 332-8 (2013).
Heterozygosity for lysosomal acid lipase E8SJM mutation and serum lipid concentrations.
Muntoni S, et al. Nutr Metab Cardiovasc Dis 23, 732-6 (2013).
Intragenic deletion as a novel type of mutation in Wolman disease.
Lee TM, et al. Mol Genet Metab 104, 703-5 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Abhydrolase_1 (pfam00561)
  alpha/beta hydrolase fold.
PLN02872 (PLN02872)
  triacylglycerol lipase.
Abhydro_lipase (pfam04083)
  Partial alpha/beta-hydrolase lipase region.
Abhydrolase_1 (pfam00561)
  alpha/beta hydrolase fold.
Abhydro_lipase (pfam04083)
  Partial alpha/beta-hydrolase lipase region.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Lipa includes H.sapiens LIPA and R.norvegicus Lipa.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Arthropoda
Insecta - insects (35 transcripts, 12 species)
Arachnida - arachnids (9 transcripts, 2 species)
Branchiopoda - crustaceans (3 transcripts, 1 species)
Maxillopoda - crustaceans (2 transcripts, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)

Chordata
Mammalia - mammals (16 transcripts, 13 species)
Actinopterygii - bony fishes (10 transcripts, 9 species)
Amniota - vertebrates (3 transcripts, 1 species)
Aves - birds (3 transcripts, 2 species)
Amphibia - amphibians (3 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (7 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (3 transcripts, 2 species)
Anthozoa - anthozoans (3 transcripts, 1 species)

Platyhelminthes
Turbellaria - flatworms (3 transcripts, 1 species)
Trematoda - flatworms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (3 transcripts, 2 species)

Streptophyta
Eudicotyledons - eudicots (18 transcripts, 15 species)
Liliopsida - monocots (5 transcripts, 4 species)
Isoetopsida - club-mosses (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (4 transcripts, 3 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Ciliophora
Oligohymenophorea - ciliates (2 transcripts, 1 species)

 

 

 

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