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HomoloGene:1572. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   GOT2,  H.sapiens
glutamic-oxaloacetic transaminase 2, mitochondrial
    NP_002071.2
430 aa
   GOT2,  P.troglodytes
glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)
    XP_523381.2
430 aa
   GOT2,  M.mulatta
glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)
    XP_001103601.1
430 aa
   GOT2,  C.lupus
glutamic-oxaloacetic transaminase 2, mitochondrial
    XP_535278.3
430 aa
   GOT2,  B.taurus
glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)
    NP_777231.1
430 aa
   Got2,  M.musculus
glutamate oxaloacetate transaminase 2, mitochondrial
    NP_034455.1
430 aa
   Got2,  R.norvegicus
glutamic-oxaloacetic transaminase 2, mitochondrial
    NP_037309.1
430 aa
   GOT2,  G.gallus
glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)
    NP_990854.1
423 aa
   got2,  X.tropicalis
glutamic-oxaloacetic transaminase 2, mitochondrial
    NP_001016933.1
427 aa
   got2b,  D.rerio
glutamic-oxaloacetic transaminase 2b, mitochondrial (aspartate aminotransferase 2)
    NP_956283.1
428 aa
   got2a,  D.rerio
glutamic-oxaloacetic transaminase 2a, mitochondrial (aspartate aminotransferase 2)
    NP_998544.1
428 aa
   Got2,  D.melanogaster
Glutamate oxaloacetate transaminase 2
    NP_722745.1
431 aa
   AgaP_AGAP009685,  A.gambiae
AgaP_AGAP009685
    XP_318743.3
430 aa
   got-2.2,  C.elegans
got-2.2
    NP_741810.1
414 aa
   got-2.1,  C.elegans
got-2.1
    NP_491413.2
419 aa
   SPBC725.01,  S.pombe
SPBC725.01
    NP_595481.1
437 aa
   MGG_06530,  M.oryzae
MGG_06530
    XP_003717017.1
405 aa
   NCU08411,  N.crassa
NCU08411
    XP_963283.2
426 aa
   NCU10383,  N.crassa
NCU10383
    XP_001728110.1
426 aa
   ASP1,  A.thaliana
ASP1
    NP_001118421.1
430 aa
   Os06g0548000,  O.sativa
Os06g0548000
    NP_001057825.1
463 aa
   Os02g0236000,  O.sativa
Os02g0236000
    NP_001046388.1
432 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

D.melanogaster
The structural gene for the more slowly anodally migrating of the two glutamate oxalacetic transaminases. Enzyme is a dimer based on formation of a hybrid molecule.



Publications
Articles associated with genes and sequences of this homology group.

Contractions but not AICAR increase FABPpm content in rat muscle sarcolemma.
Jeppesen J, et al. Mol Cell Biochem 326, 45-53 (2009).
Association study of GOT2 genetic polymorphisms and schizophrenia.
Tsai SJ, et al. Psychiatr Genet 17, 314 (2007).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Aminotran_1_2 (pfam00155)
  Aminotransferase class I and II.
AAT_I (cl18945)
  Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Got2 includes H.sapiens GOT2 and R.norvegicus Got2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (22 transcripts, 11 species)
Mammalia - mammals (21 transcripts, 16 species)
Aves - birds (3 transcripts, 3 species)
Amphibia - amphibians (3 transcripts, 2 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (13 transcripts, 12 species)
Arachnida - arachnids (3 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (3 transcripts, 2 species)
Anthozoa - anthozoans (2 transcripts, 1 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)
Turbellaria - flatworms (2 transcripts, 1 species)

Nematoda
Chromadorea - nematodes (3 transcripts, 2 species)

Porifera
Demospongiae - sponges (3 transcripts, 1 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (38 transcripts, 28 species)
Liliopsida - monocots (25 transcripts, 9 species)
Coniferopsida - conifers (3 transcripts, 3 species)
Bryopsida - mosses (1 transcript, 1 species)

Chlorophyta
Chlorophyceae - green algae (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (4 transcripts, 3 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (3 transcripts, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)
Pythiales - oomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Ciliophora
Oligohymenophorea - ciliates (3 transcripts, 2 species)

Dictyosteliida
Dictyostelium - cellular slime molds (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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