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HomoloGene:128416. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   FN1,  B.taurus
fibronectin 1
    NP_001157250.1
2387 aa
   fn1b,  D.rerio
fibronectin 1b
    NP_001013279.1
2408 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Extracellular matrix proteins differentially regulate airway smooth muscle phenotype and function.
Dekkers BG, et al. Am J Physiol Lung Cell Mol Physiol 292, L1405-13 (2007).
[Alcohol abuse as a risk factor for ARDS].
Wakabayashi I & Kato H. Nihon Arukoru Yakubutsu Igakkai Zasshi 41, 400-6 (2006).
Adherence of Pasteurella multocida to fibronectin.
Dabo SM, et al. Vet Microbiol 110, 265-75 (2005).
Partial primary structure of bovine plasma fibronectin: three types of internal homology.
Petersen TE, et al. Proc Natl Acad Sci U S A 80, 137-41 (1983).
Complete primary structure of bovine plasma fibronectin.
Skorstengaard K, et al. Eur J Biochem 161, 441-53 (1986).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
FN3 (cl00065)
  Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
FN1 (cl00063)
  Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.
FN3 (cl00065)
  Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
FN2 (cl09951)
  Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (3 transcripts, 3 species)
Actinopterygii - bony fishes (3 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

 

 

 

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