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HomoloGene:3217. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   COL12A1,  H.sapiens
collagen, type XII, alpha 1
    NP_004361.3
3063 aa
   COL12A1,  P.troglodytes
collagen, type XII, alpha 1
    XP_001142912.1
3063 aa
   COL12A1,  M.mulatta
collagen, type XII, alpha 1
    XP_001109727.2
3095 aa
   COL12A1,  C.lupus
collagen, type XII, alpha 1
    XP_005627591.1
3122 aa
   COL12A1,  B.taurus
collagen, type XII, alpha 1
    NP_001193426.1
3065 aa
   Col12a1,  M.musculus
collagen, type XII, alpha 1
    NP_031756.2
3061 aa
   Col12a1,  R.norvegicus
collagen, type XII, alpha 1
    XP_006243503.1
3110 aa
   COL12A1,  G.gallus
collagen, type XII, alpha 1
    NP_990352.1
3124 aa
   col12a1,  X.tropicalis
collagen, type XII, alpha 1
    XP_002936246.2
3113 aa
   col12a1a,  D.rerio
collagen, type XII, alpha 1a
    XP_002665305.3
3067 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

The association between the COL12A1 gene and anterior cruciate ligament ruptures.
Posthumus M, et al. Br J Sports Med 44, 1160-5 (2010).
Shear stress-induced collagen XII expression is associated with atherogenesis.
Jin X, et al. Biochem Biophys Res Commun 308, 152-8 (2003).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
fn3 (pfam00041)
  Fibronectin type III domain.
TSPN (smart00210)
  Thrombospondin N-terminal -like domains.
vWFA (cl00057)
  Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
vWFA (cl00057)
  Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
FN3 (cl00065)
  Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
Collagen (cl19732)
  Collagen triple helix repeat (20 copies).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Col12a1 includes H.sapiens COL12A1 and R.norvegicus Col12a1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (19 transcripts, 11 species)
Actinopterygii - bony fishes (5 transcripts, 3 species)
Aves - birds (3 transcripts, 2 species)
Amphibia - amphibians (3 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

 

 

 

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