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HomoloGene:1222. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PARP1,  H.sapiens
poly (ADP-ribose) polymerase 1
    NP_001609.2
1014 aa
   PARP1,  P.troglodytes
poly (ADP-ribose) polymerase 1
    XP_003949754.1
1014 aa
   PARP1,  M.mulatta
poly (ADP-ribose) polymerase 1
    XP_001090984.1
1014 aa
   PARP1,  C.lupus
poly (ADP-ribose) polymerase 1
    XP_547506.3
1043 aa
   PARP1,  B.taurus
poly (ADP-ribose) polymerase 1
    NP_777176.1
1016 aa
   Parp1,  M.musculus
poly (ADP-ribose) polymerase family, member 1
    NP_031441.2
1014 aa
   Parp1,  R.norvegicus
poly (ADP-ribose) polymerase 1
    NP_037195.1
1014 aa
   PARP1,  G.gallus
poly (ADP-ribose) polymerase 1
    NP_990594.1
1011 aa
   parp1,  X.tropicalis
poly (ADP-ribose) polymerase 1
    XP_002941174.2
1013 aa
   parp1,  D.rerio
poly (ADP-ribose) polymerase family, member 1
    NP_001038407.1
1013 aa
   Parp,  D.melanogaster
Poly-(ADP-ribose) polymerase
    NP_001104452.1
994 aa
   AgaP_AGAP003230,  A.gambiae
AgaP_AGAP003230
    XP_312938.4
995 aa
   pme-1,  C.elegans
pme-1
    NP_491072.1
945 aa
   PARP1,  A.thaliana
PARP1
    NP_850165.1
983 aa
   Os07g0413700,  O.sativa
Os07g0413700
    NP_001059453.1
977 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.




Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
zf-PARP (pfam00645)
  Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region.
PADR1 (pfam08063)
  PADR1 (NUC008) domain.
BRCT (pfam00533)
  BRCA1 C Terminus (BRCT) domain.
zf-PARP (pfam00645)
  Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region.
PADR1 (pfam08063)
  PADR1 (NUC008) domain.
BRCT (cl00038)
  Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/hetero BRCT multimers, BRCT-non-BRCT interactions, and interactions within DNA strand breaks.
ADP_ribosyl (cl00283)
  ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
WGR (cl01581)
  WGR domain.
RRS1 (cl02166)
  Ribosome biogenesis regulatory protein (RRS1).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Parp1 includes H.sapiens PARP1 and R.norvegicus Parp1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (16 transcripts, 15 species)
Actinopterygii - bony fishes (16 transcripts, 9 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Hyperoartia - vertebrates (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (9 transcripts, 8 species)
Branchiopoda - crustaceans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (3 transcripts, 1 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (21 transcripts, 17 species)
Liliopsida - monocots (9 transcripts, 7 species)
Coniferopsida - conifers (3 transcripts, 3 species)
Bryopsida - mosses (1 transcript, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (1 transcript, 1 species)

 

 

 

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