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HomoloGene:68070. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   SERPINE1,  H.sapiens
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
    NP_000593.1
402 aa
   SERPINE1,  P.troglodytes
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
    XP_527841.3
402 aa
   SERPINE1,  M.mulatta
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
    XP_001107647.1
402 aa
   SERPINE1,  C.lupus
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
    NP_001184024.1
402 aa
   SERPINE1,  B.taurus
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
    NP_776562.1
402 aa
   Serpine1,  M.musculus
serine (or cysteine) peptidase inhibitor, clade E, member 1
    NP_032897.2
402 aa
   Serpine1,  R.norvegicus
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
    NP_036752.1
402 aa
   serpine1,  X.tropicalis
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
    XP_002941247.2
403 aa
   serpine1,  D.rerio
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
    NP_001108031.1
384 aa
   SRPN1,  A.gambiae
SRPN1
    XP_308847.4
421 aa
   SRPN2,  A.gambiae
SRPN2
    XP_308845.4
409 aa
   SRPN3,  A.gambiae
SRPN3
    XP_308846.4
418 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Hemorrhagic diathesis due to PAI1 deficiency.
Thrombophilia due to excessive plasminogen activator inhibitor.



Publications
Articles associated with genes and sequences of this homology group.

Peritoneal fibrinolytic activity and adhesiogenesis.
Fometescu SG, et al. Chirurgia (Bucur) 108, 331-40 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
SERPIN (cl00137)
  SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
SERPIN (cl00137)
  SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Serpine1 includes H.sapiens SERPINE1 and R.norvegicus Serpine1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (12 transcripts, 12 species)
Actinopterygii - bony fishes (4 transcripts, 4 species)
Amphibia - amphibians (1 transcript, 1 species)

Arthropoda
Insecta - insects (1 transcript, 1 species)

 

 

 

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