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HomoloGene:264. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PROS1,  H.sapiens
protein S (alpha)
    NP_000304.2
676 aa
   PROS1,  P.troglodytes
protein S (alpha)
    XP_516603.3
676 aa
   PROS1,  M.mulatta
protein S (alpha)
    NP_001038191.1
632 aa
   PROS1,  C.lupus
protein S (alpha)
    XP_005639500.1
1077 aa
   PROS1,  B.taurus
protein S (alpha)
    NP_776863.1
675 aa
   Pros1,  M.musculus
protein S (alpha)
    NP_035303.1
675 aa
   Pros1,  R.norvegicus
protein S (alpha)
    NP_112348.2
675 aa
   PROS1,  G.gallus
protein S (alpha)
    XP_416641.2
665 aa
   pros1,  X.tropicalis
protein S (alpha)
    NP_001119539.1
673 aa
   pros1,  D.rerio
protein S (alpha)
    NP_001070791.1
673 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Protein S deficiency.



Publications
Articles associated with genes and sequences of this homology group.

Molecular basis of protein S deficiency in China.
Tang L, et al. Am J Hematol 88, 899-905 (2013).
Genotype and laboratory and clinical phenotypes of protein s deficiency.
Duebgen S, et al. Am J Clin Pathol 137, 178-84 (2012).
Maternal serum protein S forms in pregnancies complicated by intrauterine growth restriction.
De Bonis M, et al. Eur J Obstet Gynecol Reprod Biol 160, 142-6 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Laminin_G_2 (pfam02210)
  Laminin G domain.
cEGF (pfam12662)
  Complement Clr-like EGF-like.
Gla (cl02449)
  Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain.
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
cEGF (pfam12662)
  Complement Clr-like EGF-like.
vWFA (cl00057)
  Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
LamG (cl17353)
  Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Pros1 includes H.sapiens PROS1 and R.norvegicus Pros1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (13 transcripts, 13 species)
Actinopterygii - bony fishes (6 transcripts, 6 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

 

 

 

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