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HomoloGene:2162. Gene conserved in Opisthokonta Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   RAP1A,  H.sapiens
RAP1A, member of RAS oncogene family
    NP_001010935.1
184 aa
   RAP1A,  P.troglodytes
RAP1A, member of RAS oncogene family
    XP_524793.1
184 aa
   RAP1A,  M.mulatta
RAP1A, member of RAS oncogene family
    XP_001106027.1
184 aa
   RAP1A,  C.lupus
RAP1A, member of RAS oncogene family
    XP_863066.1
184 aa
   RAP1A,  B.taurus
RAP1A, member of RAS oncogene family
    NP_776873.1
184 aa
   Rap1a,  M.musculus
RAS-related protein-1a
    NP_663516.1
184 aa
   Rap1a,  R.norvegicus
RAP1A, member of RAS oncogene family
    NP_001005765.1
184 aa
   RAP1A,  G.gallus
RAP1A, member of RAS oncogene family
    XP_417994.1
184 aa
   rap1a,  X.tropicalis
RAP1A, member of RAS oncogene family
    NP_001096357.1
185 aa
   rap1aa,  D.rerio
RAP1A, member of RAS oncogene family a
    NP_001002152.1
185 aa
   rap1ab,  D.rerio
RAP1A, member of RAS oncogene family b
    NP_001230108.1
185 aa
   R,  D.melanogaster
Roughened
    NP_001189023.1
184 aa
   AgaP_AGAP001874,  A.gambiae
AgaP_AGAP001874
    XP_003435963.1
184 aa
   AGOS_AFR464W,  E.gossypii
AGOS_AFR464W
    NP_986011.1
264 aa
   MGG_02727,  M.oryzae
MGG_02727
    XP_003721031.1
216 aa
   NCU02167,  N.crassa
NCU02167
    XP_964526.2
216 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Distinct functions for Rap1 signaling in vascular morphogenesis and dysfunction.
Chrzanowska-Wodnicka M. Exp Cell Res 319, 2350-9 (2013).
Rap1 mediates protective effects of iloprost against ventilator-induced lung injury.
Birukova AA, et al. J Appl Physiol (1985) 107, 1900-10 (2009).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
P-loop_NTPase (cl09099)
  P-loop containing Nucleoside Triphosphate Hydrolases.
Ras_like_GTPase (cl17170)
  Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Rap1a includes H.sapiens RAP1A and R.norvegicus Rap1a.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (23 transcripts, 10 species)
Mammalia - mammals (13 transcripts, 12 species)
Amphibia - amphibians (4 transcripts, 2 species)
Aves - birds (3 transcripts, 3 species)
Ascidiacea - tunicates (2 transcripts, 1 species)
Amniota - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (10 transcripts, 10 species)
Branchiopoda - crustaceans (2 transcripts, 1 species)
Maxillopoda - crustaceans (2 transcripts, 1 species)
Arachnida - arachnids (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (3 transcripts, 2 species)
Turbellaria - flatworms (2 transcripts, 1 species)

Cnidaria
Anthozoa - anthozoans (3 transcripts, 1 species)
Hydrozoa - hydrozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (3 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (3 transcripts, 1 species)
Liliopsida - monocots (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (3 transcripts, 2 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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