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HomoloGene:561. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   ALOX5,  H.sapiens
arachidonate 5-lipoxygenase
    NP_000689.1
674 aa
   ALOX5,  P.troglodytes
arachidonate 5-lipoxygenase
    XP_507763.3
677 aa
   ALOX5,  M.mulatta
arachidonate 5-lipoxygenase
    XP_001102354.1
674 aa
   ALOX5,  C.lupus
arachidonate 5-lipoxygenase
    NP_001192042.1
676 aa
   ALOX5,  B.taurus
arachidonate 5-lipoxygenase
    NP_001179721.1
674 aa
   Alox5,  M.musculus
arachidonate 5-lipoxygenase
    NP_033792.1
674 aa
   Alox5,  R.norvegicus
arachidonate 5-lipoxygenase
    NP_036954.1
670 aa
   ALOX5,  G.gallus
arachidonate 5-lipoxygenase
    XP_003641560.1
674 aa
   alox5,  X.tropicalis
arachidonate 5-lipoxygenase
    XP_004915982.1
674 aa
   alox5a,  D.rerio
arachidonate 5-lipoxygenase a
    NP_001243676.1
675 aa
   LOX5,  A.thaliana
LOX5
    NP_188879.2
886 aa
   LOX1,  A.thaliana
LOX1
    NP_175900.1
859 aa
   Os03g0700400,  O.sativa
Os03g0700400
    NP_001050993.1
866 aa
   Os03g0699700,  O.sativa
Os03g0699700
    NP_001050990.1
863 aa
   Os03g0738600,  O.sativa
Os03g0738600
    NP_001051212.1
870 aa
   Os03g0700700,  O.sativa
Os03g0700700
    NP_001050995.2
787 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Atherosclerosis, susceptibility to.
Asthma, diminished response to antileukotriene treatment in.



Publications
Articles associated with genes and sequences of this homology group.

The influence of 5-lipoxygenase on cigarette smoke-induced emphysema in mice.
Kennedy-Feitosa E, et al. Biochim Biophys Acta 1840, 199-208 (2014).
5-Lipoxygenase facilitates healing after myocardial infarction.
Blömer N, et al. Basic Res Cardiol 108, 367 (2013).
5-lipoxygenase antagonist therapy: a new approach towards targeted cancer chemotherapy.
Bishayee K & Khuda-Bukhsh AR. Acta Biochim Biophys Sin (Shanghai) 45, 709-19 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Lipoxygenase (pfam00305)
  Lipoxygenase.
PLAT (cl00011)
  PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and ...
Lipoxygenase (pfam00305)
  Lipoxygenase.
PLAT (cl00011)
  PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Alox5 includes H.sapiens ALOX5 and R.norvegicus Alox5.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Streptophyta
Eudicotyledons - eudicots (117 transcripts, 34 species)
Liliopsida - monocots (27 transcripts, 8 species)
Coniferopsida - conifers (10 transcripts, 3 species)
Isoetopsida - club-mosses (1 transcript, 1 species)

Chordata
Actinopterygii - bony fishes (12 transcripts, 8 species)
Mammalia - mammals (11 transcripts, 9 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)

 

 

 

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